超重人群肝脏脂肪变性、纤维化与 2 型糖尿病发病之间的关系：一项基于纤维扫描的意大利南部研究。

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-11-07 DOI:10.1016/j.diabres.2024.111911

Davide Guido , Nicole Cerabino , Martina Di Chito , Vincenza Di Stasi , Sara De Nucci , Endrit Shahini , Vito Giannuzzi , Raffaele Cozzolongo , Sergio Coletta , Dolores Stabile , Anna Ancona , Giovanna Longo , Luigi Fontana , Gianluigi Giannelli , Giovanni De Pergola

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引用次数: 0

摘要

研究目的本研究旨在探讨 Fibroscan 评估的肝脏脂肪变性和纤维化与超重、未服药的男性和女性 2 型糖尿病发病之间的关联：我们分析了 164 名超重或肥胖参与者（41.4% 为男性）的数据，其中包括 39 名 2 型糖尿病患者（23.8%）。所有参与者都接受了纤维扫描，以评估肝脏脂肪变性（CAP > 275 dBm）和纤维化（肝脏硬度 > 8.2 kPa）。糖尿病通过空腹血糖、2 小时葡萄糖耐量试验 (OGTT) 和 HbA1c 水平进行诊断：肝脏脂肪变性在糖尿病患者中的发病率明显更高（89.7% 对 52%，P < 0.001）。35.9%的糖尿病患者出现肝纤维化（对 13.6%，P = 0.002）。糖尿病组的平均 CAP 值（P < 0.001）和 kPA 值（P = 0.006）明显更高。研究发现，CAP（MD：30.87，P = 0.009）和肝僵化（MD：2.454，P = 0.006）与糖尿病之间存在明显关联，且不受其他变量影响。此外，肝脏脂肪变性与 HOMA-IR 水平升高独立相关（P = 0.001）：结论：肝脏脂肪变性和肝纤维化的升高都与 2 型糖尿病有关，与传统的风险因素无关。这些发现支持对脂肪变性和肝纤维化明显的人进行糖尿病筛查，反之亦然。

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Association between liver steatosis, fibrosis, and the onset of type 2 diabetes in overweight individuals: A fibroscan-based study in Southern Italy

Objective

This study aims to explore the association between liver steatosis and fibrosis, as assessed by Fibroscan, and the onset of type 2 diabetes in overweight, medication-free men and women.

Methods

We analyzed data from 164 participants with overweight or obesity (41.4 % male), including 39 individuals (23.8 %) with type 2 diabetes. All participants underwent Fibroscan to evaluate liver steatosis (CAP > 275 dBm) and fibrosis (liver stiffness > 8.2 kPa). Diabetes was diagnosed using fasting glucose, 2-hour glucose tolerance test (OGTT), and HbA1c levels.

Results

Liver steatosis was significantly more prevalent in individuals with diabetes (89.7 % vs 52 %, P < 0.001). Liver fibrosis was observed in 35.9 % of subjects with diabetes (vs 13.6 %, P = 0.002). Mean CAP (P < 0.001) and kPA (P = 0.006) values were significantly higher in the group with diabetes. Significant associations between CAP (MD: 30.87, P = 0.009) and liver stiffness (MD: 2.454, P = 0.006) with diabetes were found, independent of other variables. Additionally, liver steatosis was independently associated with elevated HOMA-IR levels (P = 0.001).

Conclusion

Elevated liver steatosis and fibrosis are both linked to type 2 diabetes, independent of traditional risk factors. These findings support screening for diabetes in individuals with significant steatosis and fibrosis and vice versa.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.