Vitamin and mineral supplements: Are they associated with fatigue?

Background and aims: Vitamin/mineral supplements (VMS) and vitamin/mineral and/or dietary supplements (VMDS) are commonly consumed, based on the belief of their invigorating properties. Still, the association of VMS/VMDS with fatigue in the general population remains sparse and conclusions are mixed. This study aimed to understand the association between VMS/VMDS and fatigue.

Methods: Two cross-sectional studies (2014-2017 and 2018-2021) conducted on a population-based cohort. Participants were divided into VMS/VMDS users and non-users. Fatigue levels were assessed using the Fatigue Severity Scale (FSS) and the 14-item version of the Chalder Fatigue Scale (CFS).

Results: Overall, 2084 (50.8% female, 61.7±9.8 years) and 1728 (49.6% female, 64.1±9.3 years) were included in the first and second surveys, respectively. In the first survey, after multivariable analysis, no association was found between VMS use and FSS: adjusted mean±sem 3.04±0.13 vs. 2.82±0.03 for users and non-users, respectively, p=0.083, while users scored higher in the CFS: 6.17±0.22 vs. 5.72±0.06 for users and non-users, respectively, p=0.048. In the second survey, no association was found between VMS use and FSS (2.83±0.19 vs. 2.84±0.03, p=0.952) and CFS (5.38±0.33 vs. 5.61±0.06, p=0.504). In the first survey, VMDS users scored higher in both FSS (3.03±0.06 vs. 2.76±0.04, p<0.001) and CFS (6.19±0.11 vs. 5.58±0.06, p<0.001) while no differences were found in the second survey in both FSS (2.93±0.07 vs. 2.81±0.04, p=0.161) and CFS (5.78±0.12 vs. 5.54±0.07, p=0.088) CONCLUSION: In this population-based cross-sectional study, the authors found no consistent association between VMS consumption and fatigue. Participants taking VMDS tended to present with higher fatigue scores.