脂肪酸结合蛋白--新时代的生物标志物

IF 3.2 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Harshita Shand , Soumendu Patra , Suvankar Ghorai
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引用次数: 0

摘要

被称为脂肪酸结合蛋白(FABPs)的小型脂质结合蛋白在脂肪酸(FA)代谢水平升高的细胞中广泛表达。哺乳动物中有十种已知的 FABPs,它们的表达模式与组织和三级结构密切相关。FABPs 最初是作为细胞内的脂肪酸转运蛋白进行研究的。随后的研究表明,它们直接或通过控制基因表达参与表达细胞内的信号传递和脂质代谢。此外,有证据表明它们可能被释放出来并影响循环功能。据观察,一些与炎症、代谢疾病和传染病有关的组织和器官的 FABPs 表达水平明显升高。因此,除了先前确定的标记物之外,FABPs 还是一种很有前景的新生物标记物,需要进一步研究,以优化疾病检测和预后技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fatty acid binding protein as a new age biomarker
Small lipid-binding proteins known as fatty acid-binding proteins (FABPs) are extensively expressed in cells having elevated levels of fatty acid (FA) metabolism. There are ten known FABPs in mammals that exhibit expression patterns specific to tissues and tertiary structures that are substantially preserved. FABPs were first investigated as FA transport proteins inside cells. Subsequent research has shown that they are involved in signalling within their expression cells and in metabolism of lipid, directly and through the control of expression of gene. Additionally, there is evidence that they might be released and influence circulatory function. It has been observed that some tissues and organs linked to inflammatory, metabolic illnesses and also infectious disease have markedly elevated expression levels of FABPs. Thus, in addition to previously identified markers, FABPs represent a promising new biomarker that require additional investigation to optimise illness detection and prognosis techniques.
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来源期刊
Clinica Chimica Acta
Clinica Chimica Acta 医学-医学实验技术
CiteScore
10.10
自引率
2.00%
发文量
1268
审稿时长
23 days
期刊介绍: The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.
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