意大利成年自身免疫性肝病患者抗核抗体模式的普遍性和异质性：我们的经验

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2024-11-10 DOI:10.1016/j.cca.2024.120037

Caterina Maria Gambino , Luisa Agnello , Vincenza Calvaruso , Rosaria Vincenza Giglio , Luigi Capodicasa , Concetta Scazzone , Giuseppina Candore , Fabio Del Ben , Vito Di Marco , Marcello Ciaccio

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引用次数: 0

摘要

背景和目的：本研究旨在探讨抗核抗体（ANA）模式在肝病中的临床意义：我们纳入了 396 名因疑似自身免疫性肝病 (AILD) 而要求进行 ANA 检测的患者。我们收集了每位患者的人口统计学、临床和实验室数据：结果：患者中有 33% 患有 AILD，主要是 AIH。AC1模式在自身免疫性肝炎患者中明显更普遍，而AC21模式与原发性胆汁性胆管炎（PBC）密切相关。AC4-AC5 模式在自身免疫性肝炎和原发性胆管炎患者中较少见，但在非酒精性肝炎中更为常见。在具有 AC11、AC12 和 AC21 模式的 AILD 患者中观察到碱性磷酸酶和γ-谷氨酰转移酶水平升高：这些研究结果突显了 ANA 模式在肝脏疾病中的多样化分布，特定模式与不同的肝脏疾病密切相关。

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Prevalence and heterogeneity of antinuclear antibody patterns in adult Italian patients with autoimmune liver diseases: Our experience

Background and aim

This study aims to explore the clinical significance of antinuclear antibodies (ANA) patterns in liver diseases.

Materials and methods

We included 396 patients with a request for ANA testing for suspected autoimmune liver disease (AILD). For each patient, we collected demographical, clinical, and laboratory data.

Results

Among the patients, 33% had AILD, predominantly aiutoimmune hepatitis (AIH). The AC1 pattern was significantly more prevalent in AIH patients, while the AC21 pattern was strongly associated with primary biliary cholangitis (PBC). AC4-AC5 patterns were less frequent in AIH and PBC patients but more common in non-alcoholic hepatitis. Elevated alkaline phosphatase and gamma-glutamyl transferase levels were observed in AILD patients with AC11, AC12, and AC21 patterns.

Conclusions

These findings highlight the different distribution of ANA patterns in liver diseases, with specific patterns showing strong associations with distinct liver conditions.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.