用代谢组学导航肝脏健康:全面回顾。

IF 3.2 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Preetpal Singh, Ravinder Singh, Chirag Pasricha, Pratima Kumari
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)是全球慢性肝病的主要病因,影响着全球四分之一的人口。亚太地区的人口占全球人口的一半以上,2015年与肝脏相关的死亡病例中,亚太地区占62.6%。目前,计算机断层扫描(CT)、核磁共振(NMR)光谱和超声波等肝脏成像技术是诊断该疾病的无创成像方法。肝活检是确诊非酒精性脂肪性肝炎(NASH)的金标准检测方法。然而,样本的可变性和手术的侵袭性仍存在很大问题。许多研究都指出了纤维化和脂肪变性的各种非侵入性生物标志物,以应对诊断程序的侵入性。代谢组学可能是检测早期肝病、研究病理生理学和开发药物的一种有前途的方法。代谢组学与其他全息技术结合使用,可加深对生物系统的了解。代谢组学已成为一个突出的研究课题,为研究肝病的生物标记物提供了广泛的机会,这些标记物既敏感又具有特异性。在这篇综述中,我们介绍了近期涉及使用代谢组学方法诊断肝病的研究,这将有利于肝病的早期检测和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Navigating liver health with metabolomics: A comprehensive review
Non-alcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide, affecting one-fourth of the world’s population. With more than half of the world’s population, the Asia-Pacific region contributed 62.6 % of liver-related fatal incidents in 2015. Currently, liver imaging techniques such as computed tomography (CT), nuclear magnetic resonance (NMR) spectroscopy, and ultrasound are non-invasive imaging methods to diagnose the disease. A liver biopsy is the gold standard test for establishing the definite diagnosis of non-alcoholic steatohepatitis (NASH). However, there are still significant problems with sample variability and the procedure’s invasiveness. Numerous studies have indicated various non-invasive biomarkers for both fibrosis and steatosis to counter the invasiveness of diagnostic procedures. Metabolomics could be a promising method for detecting early liver diseases, investigating pathophysiology, and developing drugs. Metabolomics, when utilized with other omics technologies, can result in a deeper understanding of biological systems. Metabolomics has emerged as a prominent research topic, offering extensive opportunities to investigate biomarkers for liver diseases that are both sensitive and specific. In this review, we have described the recent studies involving the use of a metabolomics approach in the diagnosis of liver diseases, which would be beneficial for the early detection and treatment of liver diseases.
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来源期刊
Clinica Chimica Acta
Clinica Chimica Acta 医学-医学实验技术
CiteScore
10.10
自引率
2.00%
发文量
1268
审稿时长
23 days
期刊介绍: The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.
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