Lanyu Lu, Guohui Du, Chaogang Qi, Junru Liu, Xing Wang, Dongmei Fan, Lina Sun, Ning Wang, Bowei Liu
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According to BMI stratification, the patients were divided into normal group A (18.5 kg/m<sup>2</sup>≤BMI < 24 kg/m<sup>2</sup>), overweight group B (24.0 kg/m<sup>2</sup>≤BMI < 28 kg/m<sup>2</sup>), and obesity group C (28.0 kg/m<sup>2</sup> ≤BMI < 35 kg/m<sup>2</sup>).</p><p><strong>Results: </strong>From group A to group C, SMI (5.21±0.56 vs 5.48±0.56 vs 6.03±0.69) increased gradually (P < 0.05). Logistic regression analysis indicated that for each 1-unit increase in BMI, the risk of sarcopenia decreased by 63.2% (OR=0.368, 95% CI 0.215-0.629, P=0.000) in group A. Age (OR=1.077, 95% CI 1.015-1.144, P=0.015) and %BF (OR=1.094, 95% CI 1.010-1.186, P=0.028) increased the risk of sarcopenia by 1.077 and 1.094 times, respectively, in group B. While every 1-unit increase in BMI, the risk of sarcopenia decreased by 35% (OR=0.650, 95% CI 0.430-0.983, P=0.041) in group B. %BF (OR=1.459, 95% CI 1.093-1.949, P=0.010) increased the risk factors of sarcopenia by 1.459 times in group C.</p><p><strong>Conclusion: </strong>In postmenopausal patients with T2DM, BMI had a protective effect on the occurrence of sarcopenia within a certain range, and with the increase of BMI, the risk of sarcopenia was increasing by increased %BF levels in overweight and obese patients.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552390/pdf/","citationCount":"0","resultStr":"{\"title\":\"%BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus.\",\"authors\":\"Lanyu Lu, Guohui Du, Chaogang Qi, Junru Liu, Xing Wang, Dongmei Fan, Lina Sun, Ning Wang, Bowei Liu\",\"doi\":\"10.2147/DMSO.S484545\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the relationship between obesity indices and sarcopenia in postmenopausal patients with type 2 diabetes mellitus (T2DM) at different body mass index (BMI) levels.</p><p><strong>Patients and methods: </strong>This retrospective cross-sectional study included 298 hospitalized postmenopausal women diagnosed with T2DM. We collected demographic, biochemical, and anthropometric data on each subject. Body composition was measured using dual-energy X-ray absorptiometry (DXA), and skeletal muscle mass index (SMI) and body fat percentage (%BF) were calculated. According to BMI stratification, the patients were divided into normal group A (18.5 kg/m<sup>2</sup>≤BMI < 24 kg/m<sup>2</sup>), overweight group B (24.0 kg/m<sup>2</sup>≤BMI < 28 kg/m<sup>2</sup>), and obesity group C (28.0 kg/m<sup>2</sup> ≤BMI < 35 kg/m<sup>2</sup>).</p><p><strong>Results: </strong>From group A to group C, SMI (5.21±0.56 vs 5.48±0.56 vs 6.03±0.69) increased gradually (P < 0.05). Logistic regression analysis indicated that for each 1-unit increase in BMI, the risk of sarcopenia decreased by 63.2% (OR=0.368, 95% CI 0.215-0.629, P=0.000) in group A. Age (OR=1.077, 95% CI 1.015-1.144, P=0.015) and %BF (OR=1.094, 95% CI 1.010-1.186, P=0.028) increased the risk of sarcopenia by 1.077 and 1.094 times, respectively, in group B. 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引用次数: 0
摘要
目的：研究不同体重指数（BMI）水平的绝经后 2 型糖尿病（T2DM）患者的肥胖指数与肌肉疏松症之间的关系：这项回顾性横断面研究纳入了 298 名被诊断为 T2DM 的绝经后住院妇女。我们收集了每位受试者的人口统计学、生化和人体测量数据。我们使用双能 X 射线吸收仪（DXA）测量了身体成分，并计算了骨骼肌质量指数（SMI）和体脂百分比（%BF）。根据体重指数分层，将患者分为正常组 A（18.5 kg/m2≤BMI < 24 kg/m2）、超重组 B（24.0 kg/m2≤BMI < 28 kg/m2）和肥胖组 C（28.0 kg/m2 ≤BMI < 35 kg/m2）：从 A 组到 C 组，SMI（5.21±0.56 vs 5.48±0.56 vs 6.03±0.69）逐渐增加（P < 0.05）。逻辑回归分析表明，体重指数每增加 1 个单位，A 组患肌少症的风险就会降低 63.2%（OR=0.368，95% CI 0.215-0.629，P=0.000）；年龄（OR=1.077，95% CI 1.015-1.144，P=0.015）和%BF（OR=1.094，95% CI 1.010-1.186，P=0.028）会使患肌少症的风险增加 1.077 倍和 1.094 倍。B组中，BMI每增加1个单位，肌少症的风险降低35%（OR=0.650，95% CI 0.430-0.983，P=0.041）；C组中，%BF（OR=1.459，95% CI 1.093-1.949，P=0.010）使肌少症的风险因素增加1.459倍：结论：在绝经后的 T2DM 患者中，体重指数在一定范围内对肌少症的发生有保护作用，而随着体重指数的增加，超重和肥胖患者发生肌少症的风险会因 BF%水平的增加而增加。
%BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus.
Purpose: To investigate the relationship between obesity indices and sarcopenia in postmenopausal patients with type 2 diabetes mellitus (T2DM) at different body mass index (BMI) levels.
Patients and methods: This retrospective cross-sectional study included 298 hospitalized postmenopausal women diagnosed with T2DM. We collected demographic, biochemical, and anthropometric data on each subject. Body composition was measured using dual-energy X-ray absorptiometry (DXA), and skeletal muscle mass index (SMI) and body fat percentage (%BF) were calculated. According to BMI stratification, the patients were divided into normal group A (18.5 kg/m2≤BMI < 24 kg/m2), overweight group B (24.0 kg/m2≤BMI < 28 kg/m2), and obesity group C (28.0 kg/m2 ≤BMI < 35 kg/m2).
Results: From group A to group C, SMI (5.21±0.56 vs 5.48±0.56 vs 6.03±0.69) increased gradually (P < 0.05). Logistic regression analysis indicated that for each 1-unit increase in BMI, the risk of sarcopenia decreased by 63.2% (OR=0.368, 95% CI 0.215-0.629, P=0.000) in group A. Age (OR=1.077, 95% CI 1.015-1.144, P=0.015) and %BF (OR=1.094, 95% CI 1.010-1.186, P=0.028) increased the risk of sarcopenia by 1.077 and 1.094 times, respectively, in group B. While every 1-unit increase in BMI, the risk of sarcopenia decreased by 35% (OR=0.650, 95% CI 0.430-0.983, P=0.041) in group B. %BF (OR=1.459, 95% CI 1.093-1.949, P=0.010) increased the risk factors of sarcopenia by 1.459 times in group C.
Conclusion: In postmenopausal patients with T2DM, BMI had a protective effect on the occurrence of sarcopenia within a certain range, and with the increase of BMI, the risk of sarcopenia was increasing by increased %BF levels in overweight and obese patients.
期刊介绍：
An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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