内脏肥胖对腹腔镜胃癌切除术中荧光引导淋巴结切除术结果的影响：随机三期试验的事后分析。

IF 7 2区医学 Q1 ONCOLOGY

Chinese Journal of Cancer Research Pub Date : 2024-10-30 DOI:10.21147/j.issn.1000-9604.2024.05.04

Yihui Tang, Zening Huang, Xingqi Zhang, Ping Li, Jianwei Xie, Jiabin Wang, Qiyue Chen, Longlong Cao, Mi Lin, Ruhong Tu, Guangtan Lin, Hualong Zheng, Qing Zhong, Juli Lin, Zihao Yao, Dong Wu, Chaohui Zheng, Jianxian Lin, Changming Huang

{"title":"内脏肥胖对腹腔镜胃癌切除术中荧光引导淋巴结切除术结果的影响：随机三期试验的事后分析。","authors":"Yihui Tang, Zening Huang, Xingqi Zhang, Ping Li, Jianwei Xie, Jiabin Wang, Qiyue Chen, Longlong Cao, Mi Lin, Ruhong Tu, Guangtan Lin, Hualong Zheng, Qing Zhong, Juli Lin, Zihao Yao, Dong Wu, Chaohui Zheng, Jianxian Lin, Changming Huang","doi":"10.21147/j.issn.1000-9604.2024.05.04","DOIUrl":null,"url":null,"abstract":"Objective: To explore the impact of visceral fat area (VFA) on the short- and long-term efficacy of indocyanine green (ICG)-guided D2 lymphadenectomy for gastric cancer (GC).Methods: A post hoc analysis was performed in patients who participated in a phase 3 randomized clinical trial of ICG-guided laparoscopic radical gastrectomy vs. conventional laparoscopic radical gastrectomy from November 2018 to July 2019. The VFA was calculated based on preoperative computed tomography images. Short-term efficacy included the quality of lymph node (LN) dissection and surgical outcomes, while long-term efficacy included overall survival (OS) and recurrence-free survival (RFS).Results: This study included 126 patients each in the ICG (high-VFA, n=43) and non-ICG groups (high-VFA, n=38). Compared with the non-ICG group, the ICG group had significantly more retrieved LNs (low-VFA: 50.1 vs. 43.9, P=0.001; high-VFA: 49.6 vs. 37.5, P<0.001) and a significantly lower LN noncompliance rate (low-VFA: 32.5% vs. 50.0%, P=0.020; high-VFA: 32.6% vs. 73.7%, P<0.001), regardless of the VFA. The ICG group had a shorter postoperative hospital stay and fewer intra-abdominal infections than the ICG group in the high-VFA patients (P=0.025 and P=0.020, respectively) but not in the low-VFA patients. Regardless of the VFA, the 3-year OS (RFS) was better in the ICG group than in the non-ICG group [low-VFA: 83.1% (76.9%) vs. 73.9% (67.0%); high-VFA: 90.7% (90.7%) vs. 73.7% (73.5%); P for interaction =0.474 (0.547)].Conclusions: The short- and long-term efficacies of ICG tracing were not influenced by visceral obesity.","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"36 5","pages":"503-516"},"PeriodicalIF":7.0000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555203/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of visceral obesity on outcomes of fluorescence-guided lymphadenectomy during laparoscopic gastrectomy for gastric cancer: Post hoc analysis of a randomized phase 3 trial.\",\"authors\":\"Yihui Tang, Zening Huang, Xingqi Zhang, Ping Li, Jianwei Xie, Jiabin Wang, Qiyue Chen, Longlong Cao, Mi Lin, Ruhong Tu, Guangtan Lin, Hualong Zheng, Qing Zhong, Juli Lin, Zihao Yao, Dong Wu, Chaohui Zheng, Jianxian Lin, Changming Huang\",\"doi\":\"10.21147/j.issn.1000-9604.2024.05.04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To explore the impact of visceral fat area (VFA) on the short- and long-term efficacy of indocyanine green (ICG)-guided D2 lymphadenectomy for gastric cancer (GC).Methods: A post hoc analysis was performed in patients who participated in a phase 3 randomized clinical trial of ICG-guided laparoscopic radical gastrectomy vs. conventional laparoscopic radical gastrectomy from November 2018 to July 2019. The VFA was calculated based on preoperative computed tomography images. Short-term efficacy included the quality of lymph node (LN) dissection and surgical outcomes, while long-term efficacy included overall survival (OS) and recurrence-free survival (RFS).Results: This study included 126 patients each in the ICG (high-VFA, n=43) and non-ICG groups (high-VFA, n=38). Compared with the non-ICG group, the ICG group had significantly more retrieved LNs (low-VFA: 50.1 vs. 43.9, P=0.001; high-VFA: 49.6 vs. 37.5, P<0.001) and a significantly lower LN noncompliance rate (low-VFA: 32.5% vs. 50.0%, P=0.020; high-VFA: 32.6% vs. 73.7%, P<0.001), regardless of the VFA. The ICG group had a shorter postoperative hospital stay and fewer intra-abdominal infections than the ICG group in the high-VFA patients (P=0.025 and P=0.020, respectively) but not in the low-VFA patients. Regardless of the VFA, the 3-year OS (RFS) was better in the ICG group than in the non-ICG group [low-VFA: 83.1% (76.9%) vs. 73.9% (67.0%); high-VFA: 90.7% (90.7%) vs. 73.7% (73.5%); P for interaction =0.474 (0.547)].Conclusions: The short- and long-term efficacies of ICG tracing were not influenced by visceral obesity.\",\"PeriodicalId\":9882,\"journal\":{\"name\":\"Chinese Journal of Cancer Research\",\"volume\":\"36 5\",\"pages\":\"503-516\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555203/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Cancer Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21147/j.issn.1000-9604.2024.05.04\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Cancer Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21147/j.issn.1000-9604.2024.05.04","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的探讨内脏脂肪面积（VFA）对吲哚菁绿（ICG）引导的胃癌（GC）D2淋巴结切除术的短期和长期疗效的影响：对2018年11月至2019年7月参加ICG引导下腹腔镜根治性胃切除术与传统腹腔镜根治性胃切除术3期随机临床试验的患者进行了事后分析。VFA根据术前计算机断层扫描图像进行计算。短期疗效包括淋巴结（LN）清扫质量和手术效果，长期疗效包括总生存期（OS）和无复发生存期（RFS）：这项研究包括 ICG 组（高 VFA，43 人）和非 ICG 组（高 VFA，38 人）各 126 例患者。与非 ICG 组相比，ICG 组取回的 LN 明显更多（低 VFA：50.1 vs. 43.9，P=0.001；高 VFA：49.6 vs. 37.5，Pvs. 50.0%，P=0.020；高VFA：32.6% vs. 73.7%，Pvs. 73.9% (67.0%)；高VFA：90.7% (90.7%) vs. 73.7% (73.5%)；交互作用的P=0.474 (0.547)].结论：结论：ICG 追踪的短期和长期疗效不受内脏肥胖的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effect of visceral obesity on outcomes of fluorescence-guided lymphadenectomy during laparoscopic gastrectomy for gastric cancer: Post hoc analysis of a randomized phase 3 trial.

Objective: To explore the impact of visceral fat area (VFA) on the short- and long-term efficacy of indocyanine green (ICG)-guided D2 lymphadenectomy for gastric cancer (GC).

Methods: A post hoc analysis was performed in patients who participated in a phase 3 randomized clinical trial of ICG-guided laparoscopic radical gastrectomy vs. conventional laparoscopic radical gastrectomy from November 2018 to July 2019. The VFA was calculated based on preoperative computed tomography images. Short-term efficacy included the quality of lymph node (LN) dissection and surgical outcomes, while long-term efficacy included overall survival (OS) and recurrence-free survival (RFS).

Results: This study included 126 patients each in the ICG (high-VFA, n=43) and non-ICG groups (high-VFA, n=38). Compared with the non-ICG group, the ICG group had significantly more retrieved LNs (low-VFA: 50.1 vs. 43.9, P=0.001; high-VFA: 49.6 vs. 37.5, P<0.001) and a significantly lower LN noncompliance rate (low-VFA: 32.5% vs. 50.0%, P=0.020; high-VFA: 32.6% vs. 73.7%, P<0.001), regardless of the VFA. The ICG group had a shorter postoperative hospital stay and fewer intra-abdominal infections than the ICG group in the high-VFA patients (P=0.025 and P=0.020, respectively) but not in the low-VFA patients. Regardless of the VFA, the 3-year OS (RFS) was better in the ICG group than in the non-ICG group [low-VFA: 83.1% (76.9%) vs. 73.9% (67.0%); high-VFA: 90.7% (90.7%) vs. 73.7% (73.5%); P for interaction =0.474 (0.547)].

Conclusions: The short- and long-term efficacies of ICG tracing were not influenced by visceral obesity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chinese Journal of Cancer Research 医学-肿瘤学

自引率

9.80%

发文量

1726

审稿时长

4.5 months

期刊介绍： Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.