表皮生长因子受体-整合素相互作用参与调控胶质母细胞瘤进展过程中的阿诺伊克抗性。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Pampa Pain, Ashutosh Tripathi, Prakash P. Pillai
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引用次数: 0

摘要

血小板衍生生长因子/PDGF 受体与整合素信号之间的相互作用对于细胞响应细胞外刺激至关重要。整合素与脂质筏中的 PDGFR 相互作用激活了下游细胞信号通路,从而调节细胞增殖、细胞迁移、细胞分化和细胞死亡过程。本文讨论了 PDGFR 激活介导的受体内化、与其他细胞表面受体(尤其是细胞外基质受体、整合素)相互作用的机制,以及这些细胞机制如何开启不依赖锚定的细胞存活,从而导致抗厌氧菌性。此外,还讨论了非编码 RNA 等调控分子在获得 anoikis 抗性过程中的作用,它们可以调节自噬等多个分子和细胞过程。总之,这篇综述提供了一个新的视角,揭示了自噬、非编码 RNA、PDGFR 激活的细胞机制、PDGFR-整合素相互作用以及脂质筏的参与等细胞调控机制在获取 anoikis 抗性、调控胶质母细胞瘤进展过程中的复杂相互作用,以及开发治疗多形性胶质母细胞瘤新型疗法的潜在未来策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Involvement of PDGFR-integrin interactions in the regulation of anoikis resistance in glioblastoma progression

The interactions between platelet-derived growth factor/PDGF receptor and integrin signaling are crucial for cells to respond to extracellular stimuli. Integrin interactions with PDGFR within the lipid rafts activate downstream cellular signaling pathways that regulate cell proliferation, cell migration, cell differentiation, and cell death processes. The mechanisms underlying PDGFR activation mediated receptor internalization, interactions with other cell-surface receptors, particularly extracellular matrix receptors, integrins, and how these cellular mechanisms switch on anchorage-independent cell survival, leading to anoikis resistance are discussed. The role of regulatory molecules such as noncoding RNAs, that can modulate several molecular and cellular processes, including autophagy, in the acquisition of anoikis resistance is also discussed. Overall, the review provides a new perspective on a complex interplay of regulatory cellular machineries involving autophagy, noncoding RNAs and cellular mechanisms of PDGFR activation, PDGFR-integrin interactions, and involvement of lipids rafts in the acquisition of anoikis resistance that regulates glioblastoma progression along with potential future strategies to develop novel therapeutics for glioblastoma multiforme.

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来源期刊
Cell Biology International
Cell Biology International 生物-细胞生物学
CiteScore
7.60
自引率
0.00%
发文量
208
审稿时长
1 months
期刊介绍: Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect. These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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