从生热脂肪细胞的角度看脂质代谢和食品成分。

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mai Takada, Satoko Kawarasaki, Jungin Kwon, Zheng Ni, Haruya Takahashi, Kazuo Inoue, Tsuyoshi Goto
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引用次数: 0

摘要

棕色和米色脂肪细胞(统称为产热脂肪细胞)的高产热能力有助于全身能量消耗,是肥胖症治疗的一个有吸引力的靶点。研究发现,生热脂肪细胞的功能对调节全身碳水化合物和脂质代谢非常重要,激活生热脂肪细胞似乎对控制肥胖相关代谢紊乱(如血脂异常)有益处。最近的研究表明,特定的食物成分有可能通过各种机制激活生热脂肪细胞。其中一些不仅对啮齿动物有效,而且对人类也有效,因此有望利用这些食品成分有效预防肥胖。在这篇综述中,我们将介绍热致性脂肪细胞和食品配料对脂质代谢调节机制的最新研究成果,展示其激活热致性脂肪细胞的潜力及其内在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid metabolism and food ingredients from the perspective of thermogenic adipocytes.

The high heat-producing capacity of brown and beige adipocytes, collectively known as thermogenic adipocytes, contributes to whole-body energy expenditure and is an attractive target for the management of obesity. It has been revealed that the functions of thermogenic adipocytes are important for the regulation of whole-body carbohydrate and lipid metabolism, and the activation of thermogenic adipocytes seems to have beneficial effects for the management of obesity-related metabolic disorders, such as dyslipidemia. Recent studies have showed that specific food ingredients have the potential to activate thermogenic adipocytes via various mechanisms. Some of these are effective not only in rodents, but also in humans, and effective prevention of obesity using these food ingredients is expected. In this review, we introduce the recent findings on the regulatory mechanisms of lipid metabolism by thermogenic adipocytes and food ingredients, demonstrating the potential to activate thermogenic adipocytes and their underlying mechanisms.

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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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