D-柠檬烯可抑制 RANKL 诱导的破骨细胞分化,并在体外促进成骨细胞的活性。

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lynn McCallum, Simon W Fox
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引用次数: 0

摘要

骨质疏松症的治疗通常在骨折后进行。因此,确定安全的预防性干预措施以降低骨折风险将是有益的。一种方法是利用天然化合物的生物活性特性来改变破骨细胞和成骨细胞的活性。D-柠檬烯是柑橘类水果中一种耐受性良好的抗炎单萜,由于它对骨细胞活性的关键调节因子 NFκB 有抑制作用,因此很有前景。我们发现,柠檬烯能促进成骨细胞分化和骨结节形成,抑制 RANKL 诱导的破骨细胞形成和体外骨吸收。柠檬烯还能减少成骨细胞提供的促吸收信号,增强成骨细胞分化标志物(碱性磷酸酶、sterix 和骨钙素),并显著减少破骨细胞生成细胞因子(PTHrP、IL-1β 和 TNF-α)的产生。因此,补充柠檬烯是结合当前干预措施优化骨细胞活性以保持或提高骨量的一种潜在途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
D-limonene suppresses RANKL-induced osteoclast differentiation and promotes osteoblast activity in-vitro.

Treatments for osteoporosis are typically given post-fracture. Therefore, identifying safe prophylactic interventions to reduce fracture risk would be beneficial. One approach is to utilise the bioactive properties of natural compounds to modify osteoclast and osteoblast activity. D-limonene a well-tolerated, anti-inflammatory monoterpene found in citrus fruits holds promise due to its suppressive effect on NFκB, a key regulator of bone cell activity. We found that limonene promoted osteoblast differentiation and bone nodule formation and inhibited RANKL-indued osteoclast formation and bone resorption in-vitro. Limonene also reduced the pro-resorptive signal provided by osteoblast, augmenting markers of osteoblast differentiation (alkaline phosphatase, osterix and osteocalcin) and significantly decreased osteoclastogenic cytokine production (PTHrP, IL-1β and TNF-α). Therefore, limonene supplementation represents a potential route in combination with current interventions to optimise bone cell activity to maintain or enhance bone mass.

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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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