皮肌炎 I 型干扰素评分的评估、系统综述和荟萃分析。

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2024-11-07 DOI:10.1016/j.autrev.2024.103686

Chiara Castellini , Claudia Scotti , Luca Navarini , Qiong Fu , Jinjing Qian , Roberto Giacomelli , Lorenzo Cavagna , Piero Ruscitti

{"title":"皮肌炎 I 型干扰素评分的评估、系统综述和荟萃分析。","authors":"Chiara Castellini , Claudia Scotti , Luca Navarini , Qiong Fu , Jinjing Qian , Roberto Giacomelli , Lorenzo Cavagna , Piero Ruscitti","doi":"10.1016/j.autrev.2024.103686","DOIUrl":null,"url":null,"abstract":"<div><div>Dermatomyositis (DM) is a rare autoimmune systemic disorder manifesting with typical skin rashes and proximal muscle weakness. A specific clinical DM subset is characterized by the presence of the anti–melanoma differentiation–associated protein 5 (MDA5) autoantibodies. These patients are usually burdened by a severe clinical phenotype exhibiting a poor prognosis. Interestingly, a growing body of evidence has shown that (interferon) IFN signature evaluation by the assessment of type I IFN score could be a possible mechanistic biomarker for these more severe patients with DM. Thus, in this work, the difference in type I IFN score between patients with DM and healthy controls (HCs), lacking systematic synthesis of available evidence, was assessed. Moreover, the possible difference in type I IFN score between patients with DM with or without MDA5 autoantibodies was investigated.</div><div>A systematic review with a meta-analysis of available literature about values of type I IFN was performed in DM and HCs. A literature search was carried out in MEDLINE, SCOPUS, and WEB OF SCIENCE databases to identify all possible relevant studies published up to May 2024 in English language.</div><div>Four studies met the inclusion criteria, comparing type I IFN score between patients with DM and HCs, or between patients with or without anti-MDA5 autoantibodies. The type I IFN score was significantly higher in patients affected by DM when compared with HCs (pooled SMD = 2.27; 95 % CI: 0.71, 3.82; <em>p</em> = 0.004, I<sup>2</sup> = 96 %, p<sub>for heterogeneity</sub> < 0.00001) and in patients with anti-MDA5 autoantibodies than those without (pooled SMD = 0.88; 95 % CI: 0.06, 1.70; <em>p</em> = 0.03, I<sup>2</sup> = 83 %, p<sub>for heterogeneity</sub> = 0.01).</div><div>In this systematic review and meta-analysis, higher values of type I IFN score were retrieved in patients with DM when compared with HCs and in patients with anti-MDA5 autoantibodies with respect to those without. Thus, the assessment of type I IFN score appears to be a valuable mechanistic biomarker to clinically profile DM patients, and particularly those with anti-MDA5 autoantibodies.</div></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":"23 12","pages":"Article 103686"},"PeriodicalIF":9.2000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The evaluation of type I interferon score in dermatomyositis, a systematic review and a meta-analysis\",\"authors\":\"Chiara Castellini , Claudia Scotti , Luca Navarini , Qiong Fu , Jinjing Qian , Roberto Giacomelli , Lorenzo Cavagna , Piero Ruscitti\",\"doi\":\"10.1016/j.autrev.2024.103686\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Dermatomyositis (DM) is a rare autoimmune systemic disorder manifesting with typical skin rashes and proximal muscle weakness. A specific clinical DM subset is characterized by the presence of the anti–melanoma differentiation–associated protein 5 (MDA5) autoantibodies. These patients are usually burdened by a severe clinical phenotype exhibiting a poor prognosis. Interestingly, a growing body of evidence has shown that (interferon) IFN signature evaluation by the assessment of type I IFN score could be a possible mechanistic biomarker for these more severe patients with DM. Thus, in this work, the difference in type I IFN score between patients with DM and healthy controls (HCs), lacking systematic synthesis of available evidence, was assessed. Moreover, the possible difference in type I IFN score between patients with DM with or without MDA5 autoantibodies was investigated.</div><div>A systematic review with a meta-analysis of available literature about values of type I IFN was performed in DM and HCs. A literature search was carried out in MEDLINE, SCOPUS, and WEB OF SCIENCE databases to identify all possible relevant studies published up to May 2024 in English language.</div><div>Four studies met the inclusion criteria, comparing type I IFN score between patients with DM and HCs, or between patients with or without anti-MDA5 autoantibodies. The type I IFN score was significantly higher in patients affected by DM when compared with HCs (pooled SMD = 2.27; 95 % CI: 0.71, 3.82; <em>p</em> = 0.004, I<sup>2</sup> = 96 %, p<sub>for heterogeneity</sub> < 0.00001) and in patients with anti-MDA5 autoantibodies than those without (pooled SMD = 0.88; 95 % CI: 0.06, 1.70; <em>p</em> = 0.03, I<sup>2</sup> = 83 %, p<sub>for heterogeneity</sub> = 0.01).</div><div>In this systematic review and meta-analysis, higher values of type I IFN score were retrieved in patients with DM when compared with HCs and in patients with anti-MDA5 autoantibodies with respect to those without. Thus, the assessment of type I IFN score appears to be a valuable mechanistic biomarker to clinically profile DM patients, and particularly those with anti-MDA5 autoantibodies.</div></div>\",\"PeriodicalId\":8664,\"journal\":{\"name\":\"Autoimmunity reviews\",\"volume\":\"23 12\",\"pages\":\"Article 103686\"},\"PeriodicalIF\":9.2000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autoimmunity reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1568997224001770\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autoimmunity reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568997224001770","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

皮肌炎（Dermatomyositis，DM）是一种罕见的自身免疫性系统疾病，表现为典型的皮疹和近端肌肉无力。临床上有一种特殊的皮肌炎亚型，其特征是存在抗黑色素瘤分化相关蛋白 5（MDA5）自身抗体。这些患者通常临床表现严重，预后不良。有趣的是，越来越多的证据表明，通过评估 I 型 IFN 评分来评估（干扰素）IFN 标志可能是这些病情较重的 DM 患者的一种机理生物标志物。因此，在这项工作中，我们在缺乏对现有证据进行系统综合的情况下，评估了 DM 患者与健康对照组（HCs）之间 I 型 IFN 评分的差异。此外，还研究了有或没有MDA5自身抗体的DM患者的I型IFN得分可能存在的差异。对现有文献中有关 DM 和 HC 的 I 型 IFN 值进行了系统回顾和荟萃分析。我们在 MEDLINE、SCOPUS 和 WEB OF SCIENCE 数据库中进行了文献检索，以确定截至 2024 年 5 月发表的所有可能的相关英文研究。有四项研究符合纳入标准，它们比较了 DM 患者和 HC 患者之间或有无抗 MDA5 自身抗体患者之间的 I 型 IFN 评分。与HCs相比，DM患者的I型IFN得分明显更高（汇总SMD = 2.27; 95 % CI: 0.71, 3.82; p = 0.004, I2 = 96 %, pfor heterogeneity 2 = 83 %, pfor heterogeneity = 0.01）。在该系统综述和荟萃分析中，与 HCs 相比，DM 患者的 I 型 IFN 评分值更高，与无抗 MDA5 自身抗体的患者相比，有抗 MDA5 自身抗体的患者的 I 型 IFN 评分值更高。因此，I型IFN评分的评估似乎是临床分析DM患者，尤其是抗MDA5自身抗体患者的一个有价值的机理生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The evaluation of type I interferon score in dermatomyositis, a systematic review and a meta-analysis

Dermatomyositis (DM) is a rare autoimmune systemic disorder manifesting with typical skin rashes and proximal muscle weakness. A specific clinical DM subset is characterized by the presence of the anti–melanoma differentiation–associated protein 5 (MDA5) autoantibodies. These patients are usually burdened by a severe clinical phenotype exhibiting a poor prognosis. Interestingly, a growing body of evidence has shown that (interferon) IFN signature evaluation by the assessment of type I IFN score could be a possible mechanistic biomarker for these more severe patients with DM. Thus, in this work, the difference in type I IFN score between patients with DM and healthy controls (HCs), lacking systematic synthesis of available evidence, was assessed. Moreover, the possible difference in type I IFN score between patients with DM with or without MDA5 autoantibodies was investigated.

A systematic review with a meta-analysis of available literature about values of type I IFN was performed in DM and HCs. A literature search was carried out in MEDLINE, SCOPUS, and WEB OF SCIENCE databases to identify all possible relevant studies published up to May 2024 in English language.

Four studies met the inclusion criteria, comparing type I IFN score between patients with DM and HCs, or between patients with or without anti-MDA5 autoantibodies. The type I IFN score was significantly higher in patients affected by DM when compared with HCs (pooled SMD = 2.27; 95 % CI: 0.71, 3.82; p = 0.004, I² = 96 %, p_{for heterogeneity} < 0.00001) and in patients with anti-MDA5 autoantibodies than those without (pooled SMD = 0.88; 95 % CI: 0.06, 1.70; p = 0.03, I² = 83 %, p_{for heterogeneity} = 0.01).

In this systematic review and meta-analysis, higher values of type I IFN score were retrieved in patients with DM when compared with HCs and in patients with anti-MDA5 autoantibodies with respect to those without. Thus, the assessment of type I IFN score appears to be a valuable mechanistic biomarker to clinically profile DM patients, and particularly those with anti-MDA5 autoantibodies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.