叶酸受体α靶向抗体-药物共轭物疗法对高级别上皮性卵巢癌、原发性腹膜癌或输卵管癌患者的有效性和安全性：系统回顾与元分析》。

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2024-11-11 DOI:10.1002/cam4.70392

Eun Taeg Kim, Ji Hyun Kim, Eun Young Park, In Hye Song, Han Song Park, Sang-Yoon Park, Myong Cheol Lim

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引用次数: 0

摘要

背景：抗体-药物共轭物（ADC）已成为治疗复发性卵巢癌的一种极具前景的全身性选择。本研究旨在评估叶酸受体α（FRα）靶向ADC的疗效、相关的治疗相关不良事件（TRAEs）及其对治疗安全性的影响：我们进行了一次电子检索，以确定针对FRα的单药ADC以及与化疗联合治疗复发性卵巢癌的前瞻性试验。我们对客观反应率（ORR）和TRAEs的相关信息进行了汇总分析，并调查了基于FRα受体表达水平的亚组差异。研究方案已在 PROSPERO（CRD42023491151）注册：本次荟萃分析共纳入了 10 项研究，共计 940 名患者（859 名患者使用米韦妥珠单抗-索拉坦辛-gynx（MIRV）治疗，45 名患者使用法瑞珠单抗-埃克替布林（MORAb-202）治疗，36 名患者使用卢维他单抗-塔泽维布林（STRO-002）治疗）。根据汇总数据，整个队列的ORR为37%（95% CI：0.30-0.43），而高FRα表达组的ORR为34%（95% CI：0.26-0.42）。≥3级不良事件的发生率为27%（95% CI：0.19-0.36）：结论：包括MIRV在内的FRα靶向ADC具有确切的疗效和良好的安全性，是晚期或复发性卵巢癌二线及以上治疗的新选择。FRα高表达患者的ORR和PFS获益与总体队列中的患者相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Efficacy and Safety of Folate Receptor α-Targeted Antibody-Drug Conjugate Therapy in Patients With High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers: A Systematic Review and Meta-Analysis

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Background

Antibody-drug conjugates (ADC) have emerged as a highly promising systemic option in the treatment of recurrent ovarian cancer. The present study aimed to evaluate the treatment efficacy of folate receptor α (FRα)-targeting ADCs, associated treatment-related adverse events (TRAEs), and their impact on treatment safety.

Methods

We conducted an electronic search to identify prospective trials of single-agent ADCs targeting FRα and those combined with chemotherapy in recurrent ovarian cancer. Information regarding the objective response rate (ORR) and TRAEs was collectively analyzed, and differences in subgroups based on FRα receptor expression levels were investigated. The protocol was registered with PROSPERO (CRD42023491151).

Results

Ten studies with a total of 940 patients (859 treated with Mirvetuximab soravtansine-gynx (MIRV)), 45 with Farletuzumab Ecteribulin (MORAb-202), and 36 with Luveltamab Tazevibulin (STRO-002) were included in this meta-analysis. Based on the pooled data, the ORR of the entire cohort was 37% (95% CI: 0.30–0.43), while that of the high-FRα expression group was 34% (95% CI: 0.26–0.42). The incidence of grade ≥ 3 adverse events was 27% (95% CI: 0.19–0.36).

Conclusion

FRα-targeting ADCs, including MIRV, demonstrated definite efficacy and good safety as novel choices for second-line and beyond treatment of advanced or recurrent ovarian cancer. Patients with high FRα expression showed ORR and PFS benefits similar to those in the overall cohort.

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.