何首乌多糖：治疗神经退行性疾病的有效策略。

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2024-11-13 DOI:10.1016/j.neuint.2024.105902

Xue Jiang , Yumei Wang , Zhaochen Lin , Chao Li , Qian Wang , Junyan Zhang , Xiuhua Liu , Ziye Li , Chao Cui

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引用次数: 0

摘要

神经退行性疾病（NDDs）是一种以神经元变性和死亡为特征的神经系统疾病，严重威胁人类健康，由于其发病机制复杂，治疗药物疗效不佳，长期以来一直备受关注。现有研究表明，何首乌多糖（PSP）具有免疫调节、抗氧化、抗炎等药理作用，其神经保护作用已在多项科学研究中得到证实。本文综述了 PSP 在保护和治疗 NDD 方面的主要药理作用和机制，为 PSP 在 NDD 方面的临床应用和基础研究提供参考。

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Polygonatum sibiricum polysaccharides: A promising strategy in the treatment of neurodegenerative disease

Neurodegenerative diseases (NDDs), as a neurological disorder characterised by neuronal degeneration and death, are a serious threat to human health and have long attracted attention due to their complex pathogenesis and the ineffectiveness of therapeutic drugs. Existing studies have shown that Polygonatum Sibiricum polysaccharides (PSP) have immunoregulatory, antioxidant, anti-inflammatory and other pharmacological effects, and their neuroprotective effects have been demonstrated in several scientific studies. This paper reviews the main pharmacological effects and mechanisms of PSP in the protection and treatment of NDDs, to provide a reference for the clinical application and basic research of PSP in NDDs.

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.