重新审视 GBB 反应并重新定义其在药物化学中的相关性：综述。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-11-08 DOI:10.1016/j.drudis.2024.104237

Pratibha Shukla , Chandra Sourabh Azad , Deepa Deswal , Anudeep Kumar Narula

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引用次数: 0

摘要

多组分反应（MCR）在合成化学领域具有重要意义，近来，MCR 的一种变体，即格鲁贝克-布莱克本-比奈梅（GBB）反应，在合成具有重要生物学意义的支架方面引起了广泛关注。本综述详细介绍了 GBB 反应的化学进展，重点是各种催化系统的作用。此外，GBB 反应的作用已被重新定义为合成一系列潜在生物活性化合物的标准方案。

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Revisiting the GBB reaction and redefining its relevance in medicinal chemistry: A review

Multicomponent reactions (MCRs) have significant relevance in the field of synthetic chemistry, and in recent times one of the MCR variants, named the Groebke–Blackburn–Bienaymé (GBB) reaction, has attracted massive attention for the synthesis of biologically important scaffolds. The present review elaborates on the chemical advancement reported for the GBB reaction with an emphasis on the role of various catalytic systems. Further, the role of the GBB reaction has been redefined as a standard protocol for the synthesis of an array of potential bioactive compounds.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.