BitterDB：2024 年苦味配体和味觉受体的最新情况

IF 16.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2024-11-13 DOI:10.1093/nar/gkae1044

Evgenii Ziaikin, Moran David, Sofya Uspenskaya, Masha Y Niv

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引用次数: 0

摘要

BitterDB (http://bitterdb.agri.huji.ac.il) 于 2012 年推出，是苦味分子及其受体信息的中心资源，并于 2019 年更新。BitterDB 中的信息可用于探索苦味化学空间、为实验研究选择合适的配体、分析受体的选择性和杂合性以及开发味觉机器学习预测器等任务。在此，我们介绍了数据库的一次重大升级，包括内容的显著增加和新功能。BitterDB 现在拥有 2200 多种苦味分子。对于 700 个分子，至少报告了一个相关的苦味受体（TAS2R）。配体与 TAS2R 关联的总数量现已接近 1800 个。BitterDB 已扩展到总共 66 个物种（包括狗、鸟类、鱼类和灵长类动物）。随着 AlphaFold 和相关方法在计算结构预测方面的进展，以及冷冻电镜对 TAS2R 结构的实验测定，BitterDB 提供了 TAS2R 的可用结构链接。

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BitterDB: 2024 update on bitter ligands and taste receptors

BitterDB (http://bitterdb.agri.huji.ac.il) was introduced in 2012 as a central resource for information on bitter-tasting molecules and their receptors, and was updated in 2019. The information in BitterDB is used for tasks such as exploring the bitter chemical space, choosing suitable ligands for experimental studies, analyzing receptors’ selectivity and promiscuity, and developing machine learning predictors for taste. Here, we describe a major upgrade of the database, including significant increase in content as well as new features. BitterDB now holds over 2200 bitter molecules. For ∼700 molecules, at least one associated bitter taste receptor (TAS2R) is reported. The overall number of ligand-TAS2R associations is now close to 1800. BitterDB is extended to a total of 66 species (including dog, birds, fishes and primates). Following advances in computational structure prediction by AlphaFold and related methods, and the experimental determination of TAS2R structures by cryo-electron microscopy, BitterDB provides links to available structures of TAS2Rs.

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.