被对胆固醇的爱所束缚转运体邂逅 GPCR

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-11-14 DOI:10.1016/j.cell.2024.10.033

Divyanshu Tiwari, Nabarun Roy, Arun K. Shukla

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引用次数: 0

摘要

Bayly-Jones 等人最近在《自然》杂志上发表文章，报告了溶酶体胆固醇传感器 LYCHOS（又称 GPR155）的低温电子显微镜结构，揭示了植物辅酶转运体样结构域与七跨膜 GPCR 样结构域的独特融合，并阐明了细胞调控 mTORC1 活性的机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bound by the love for cholesterol: A transporter meets a GPCR

In a recently published article in Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporter-like domain with a seven-transmembrane GPCR-like domain and elucidates mechanistic insights into cellular regulation of mTORC1 activity.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.