{"title":"破解三重螺旋","authors":"Michael J. Diaz","doi":"10.1038/s41570-024-00668-1","DOIUrl":null,"url":null,"abstract":"A novel method to detect proteins interacting with triplex DNA in living cells has been developed. This approach provides new insights into triplex DNA regulation and highlights potential therapeutic targets to prevent DNA damage.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"3 1","pages":""},"PeriodicalIF":38.1000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cracking the triple helix\",\"authors\":\"Michael J. Diaz\",\"doi\":\"10.1038/s41570-024-00668-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel method to detect proteins interacting with triplex DNA in living cells has been developed. This approach provides new insights into triplex DNA regulation and highlights potential therapeutic targets to prevent DNA damage.\",\"PeriodicalId\":18849,\"journal\":{\"name\":\"Nature reviews. Chemistry\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":38.1000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews. Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1038/s41570-024-00668-1\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews. Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1038/s41570-024-00668-1","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
我们开发了一种新方法来检测活细胞中与三重 DNA 相互作用的蛋白质。这种方法提供了有关三重 DNA 调节的新见解,并突出了防止 DNA 损伤的潜在治疗目标。
A novel method to detect proteins interacting with triplex DNA in living cells has been developed. This approach provides new insights into triplex DNA regulation and highlights potential therapeutic targets to prevent DNA damage.
期刊介绍:
Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.