治疗细菌感染的抗菌 GL13K 肽装饰氧化锌纳米粒子

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2024-11-14 DOI:10.1021/acs.langmuir.4c03206

Xu Zhang, Yinghao Liu, Xue’e Zhang, Mengzhen Tang, Weihong Xi, Junchao Wei

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引用次数: 0

摘要

作为一种广谱抗菌材料，氧化锌纳米粒子（NPs）为临床治疗感染性伤口提供了一种新方法；然而，如何提高氧化锌的抗菌性能以满足临床需求是非常必要的。本研究通过聚多巴胺（PDA）作为共价键合剂，将抗菌肽 GL13K 附着在 ZnO NPs 表面，制备了一种新型的抗菌杂化 ZnO@PDA/GL13K，这种杂化 ZnO@PDA/GL13K 可增强活性氧（ROS）的产生并破坏细胞壁，显示出卓越的抗菌功效。此外，ZnO@PDA/GL13K 杂化物还能促进细菌感染伤口的愈合，伤口面积在第 9 天仅剩余 1.8%，比 ZnO 组小约 2 倍。此外，ZnO@PDA/GL13K 还表现出良好的生物相容性，对正常组织和器官没有副作用，这意味着该抗菌杂化物在生物医学领域具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

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Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields.

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).