From songbird to humans: The multifaceted roles of FOXP2 in speech and motor learning

Motor learning involves a complex network of brain structures and is crucial for tasks like speech. The cerebral cortex, subcortical nuclei, and cerebellum are involved in motor learning and vocalization. Vocal learning has been demonstrated across species. However, it is a task that should be further studied and reevaluated, particularly in species considered non-vocal learners, to potentially uncover new insights. FOXP2, a transcription factor, has been implicated in speech learning and execution. Several variants have been involved in speech and cognitive impairments; the most studied is the R553H, found in the KE family, where more than half of the members show verbal dyspraxia. Brain FOXP2 expression shows consistent patterns across species in regions associated with motor learning and execution. Animal models expressing mutated FOXP2 showed impaired motor learning and vocalization. Genes regulated by FOXP2 are related to neural differentiation, connectivity, and synaptic plasticity, indicating its role in brain development and function. This review explores the intricate relationship between FOXP2, motor learning, and speech in an anatomical and functional context.