非 FDG 缺氧示踪剂。

IF 4.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2024-11-01 DOI:10.1053/j.semnuclmed.2024.10.001

Kgomotso M.G Mokoala MD, PhD , Mike M. Sathekge MD, PhD

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引用次数: 0

摘要

缺氧在肿瘤生物学中起着至关重要的作用，影响着癌症进展、治疗耐药性和患者预后。虽然 18 氟荧光脱氧葡萄糖（[18F]F-FDG）PET 成像一直是代谢评估的标准，但它在准确描绘缺氧肿瘤区域方面存在局限性，因此有必要探索非 FDG 缺氧示踪剂。本综述旨在评估新兴的非 FDG 放射性示踪剂，如硝基咪唑衍生物、铜制剂、镓制剂和其他创新化合物，重点介绍其作用机制、生物分布和临床应用。我们将讨论与缺氧成像相关的优势和挑战，以及可增强肿瘤缺氧评估的成像技术的最新进展。通过综合当前的研究，本综述旨在深入探讨非 FDG 缺氧示踪剂在改善癌症诊断、治疗计划和监测方面的潜力，最终促进更加个性化和有效的癌症治疗。

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Non-FDG hypoxia tracers

Hypoxia plays a critical role in tumor biology, influencing cancer progression, treatment resistance, and patient prognosis. While 18-Fluorine fluoredeoxyglucose ([18F]F-FDG) PET imaging has been the standard for metabolic assessment, its limitations in accurately depicting hypoxic tumor regions necessitate the exploration of non-FDG hypoxia tracers. This review aims to evaluate emerging non-FDG radiotracers, such as nitroimidazole derivatives, copper-based agents, gallium-based agents and other innovative compounds, highlighting their mechanisms of action, biodistribution, and clinical applications. We will discuss the advantages and challenges associated with hypoxia imaging, as well as recent advancements in imaging techniques that enhance the assessment of tumor hypoxia. By synthesizing current research, this review seeks to provide insights into the potential of non-FDG hypoxia tracers for improving cancer diagnosis, treatment planning, and monitoring, ultimately contributing to more personalized and effective cancer care.

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.