胃肠道癌症中的乳酸和乳化作用:当前进展与前景(综述)。

IF 3.8 3区 医学 Q2 ONCOLOGY
Oncology reports Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI:10.3892/or.2024.8839
Yufen He, Yaxi Huang, Peng Peng, Qi Yan, Lidan Ran
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引用次数: 0

摘要

胃肠癌的发病率和死亡率都很高,它受到新陈代谢重编程的影响,尤其是乳酸的产生和积累增加。乳酸化是一种由乳酸驱动的翻译后修饰,是消化道癌症中基因表达和细胞功能的关键调节因子。本综述旨在探讨消化道癌症中乳酸和乳化作用的研究进展。本综述探讨了乳酸盐产生的机制、乳酸盐对肿瘤微环境的影响以及乳酸盐水平作为潜在生物标志物的临床意义。此外,还研究了乳酸化,包括其生化基础、主要靶点和功能结果。本综述强调了针对乳酸代谢和乳酸化的潜在治疗策略。挑战和未来方向强调了乳酸和乳酰化作为消化道癌症创新治疗靶点的潜力,以改善临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review).

Gastrointestinal (GI) cancers, which have notable incidence and mortality, are impacted by metabolic reprogramming, especially the increased production and accumulation of lactate. Lactylation, a post‑translational modification driven by lactate, is a crucial regulator of gene expression and cellular function in GI cancer. The present review aimed to examine advancements in understanding lactate and lactylation in GI cancer. The mechanisms of lactate production, its influence on the tumor microenvironment and the clinical implications of lactate levels as potential biomarkers were explored. Furthermore, lactylation was investigated, including its biochemical foundation, primary targets and functional outcomes. The present review underscored potential therapeutic strategies targeting lactate metabolism and lactylation. Challenges and future directions emphasize the potential of lactate and lactylation as innovative therapeutic targets in GI cancer to improve clinical outcomes.

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来源期刊
Oncology reports
Oncology reports 医学-肿瘤学
CiteScore
8.50
自引率
2.40%
发文量
187
审稿时长
3 months
期刊介绍: Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.
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