CRISPR 介导的非编码 RNA 沉默：一种治疗前列腺癌的新方法。

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-11-06 DOI:10.1016/j.prp.2024.155710

Mobina Tabibian, Soudeh Ghafouri-Fard

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引用次数: 0

摘要

非编码 RNA 会影响不同组织（如前列腺）的致癌过程。这些转录本中有几种是导致前列腺癌的致癌基因。因此，它们是治疗这类癌症的潜在靶点。CRISPR/Cas9 技术为调节这些癌基因的表达提供了新的工具，以对抗癌变的几个方面，包括侵袭级联和转移。本综述旨在介绍利用CRISPR/Cas9技术调节前列腺癌非编码RNA表达的新成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CRISPR-mediated silencing of non-coding RNAs: A novel putative treatment for prostate cancer.

Non-coding RNAs affect carcinogenic processes in diverse tissues, such as prostate. Several of these transcripts act as oncogenes driving prostate cancer. Thus, they are putative targets for treatment of this type of cancer. CRISPR/Cas9 technology has provided new tools for modulation of expression of these oncogenes in order to combat several aspects of carcinogenesis, including invasion cascades and metastasis. This review aimed to describe novel achievements in modulation of expression of non-coding RNAs using CRISPR/Cas9 technology in prostate cancer.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.