人工骨支架的形状/属性协同智能制造:结构设计和增材制造工艺。

IF 8.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Pei Feng, Lingxi Liu, Feng Yang, Rui Min, Ping Wu, Cijun Shuai
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引用次数: 0

摘要

人工骨移植因避免了自体移植物来源有限以及异体移植物易感染的缺点,成为目前骨缺损修复领域的研究热点。然而,传统的设计和制造方法无法制造出能很好地模拟复杂的骨样形状、相互连接的多孔结构以及与人体天然骨相似的多种特性的骨支架。增材制造可实现植入物的外部轮廓定制和内部微孔结构的可控制造,通过逐层工艺几乎可以形成任何形状的设计骨支架。增材制造技术在人工骨支架的制造中大有可为,只有将优秀的结构设计与适当的增材制造工艺相结合,才能制造出具有理想生物和机械性能的骨支架。本文总结分析了骨支架的最新设计和快速成型制造方法,以实现形状/性能协同的智能制造。骨支架设计主要分为基于单元细胞的设计和基于整体结构的设计,而基础快速成型制造和三维生物打印是骨支架制造的推荐适用快速成型制造方法。此外,还讨论了增材制造骨支架所面临的挑战和未来展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shape/properties collaborative intelligent manufacturing of artificial bone scaffold: structural design and additive manufacturing process.

Artificial bone graft stands out for avoiding limited source of autograft as well as susceptibility to infection of allograft, which makes it a current research hotspot in the field of bone defect repair. However, traditional design and manufacturing method cannot fabricate bone scaffold that well mimics complicated bone-like shape with interconnected porous structure and multiple properties akin to human natural bone. Additive manufacturing, which can achieve implant's tailored external contour and controllable fabrication of internal microporous structure, is able to form almost any shape of designed bone scaffold via layer-by-layer process. As additive manufacturing is promising in building artificial bone scaffold, only combining excellent structural design with appropriate additive manufacturing process can produce bone scaffold with ideal biological and mechanical properties. In this article, we sum up and analyze state of art design and additive manufacturing methods for bone scaffold to realize shape/properties collaborative intelligent manufacturing. Scaffold design can be mainly classified into design based on unit cells and whole structure, while basic additive manufacturing and 3D bioprinting are the recommended suitable additive manufacturing methods for bone scaffold fabrication. The challenges and future perspectives in additive manufactured bone scaffold are also discussed.

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来源期刊
Biofabrication
Biofabrication ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
17.40
自引率
3.30%
发文量
118
审稿时长
2 months
期刊介绍: Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).
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