使用手性仲胺有机催化剂全合成生物碱的最新进展。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-08 DOI:10.1039/d4ob01590h

Yuta Nakashima, Kenta Rakumitsu, Hayato Ishikawa

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引用次数: 0

摘要

自 21 世纪初以来，有机催化反应取得了重大进展。值得注意的是，许多利用手性仲胺催化剂的不对称反应已被开发并应用于天然产物的全合成。在本综述中，我们概述了自 2017 年以来报道的生物碱合成，按支架分类，重点介绍了涉及仲胺有机催化剂催化的不对称反应的关键步骤。

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Recent advances in the total synthesis of alkaloids using chiral secondary amine organocatalysts.

Since the early 21st century, organocatalytic reactions have undergone significant advancements. Notably, numerous asymmetric reactions utilizing chiral secondary amine catalysts have been developed and applied in the total synthesis of natural products. In this review, we provide an overview of alkaloid syntheses reported since 2017, categorized by scaffold, with a focus on key steps involving asymmetric reactions catalyzed by secondary amine organocatalysts.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.