接触邻苯二甲酸盐与血清尿酸和高尿酸血症风险的关系，以及全身免疫炎症的中介作用。

IF 6.2 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2024-11-15 DOI:10.1016/j.ecoenv.2024.117269

Zhiping Niu , Tianyi Chen , Zhizhou Duan , Shichao Han , Yifan Shi , Wenyuan Yu , Shuang Du , Hao Tang , Wenpu Shao , Jin Sun , Han Chen , Yunfei Cai , Yanyi Xu , Zhuohui Zhao

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引用次数: 0

摘要

背景：以前的研究发现，尿液中邻苯二甲酸盐（PAEs）代谢物可能与血清尿酸浓度升高和高尿酸血症风险有关。然而，还没有一项基于人群的研究调查了其潜在的生物学机制：这项全国性横断面研究分析了美国国家健康与营养调查（NHANES）2003-2018 年的数据。测定了尿液中的 PAEs 代谢物，并将 8 种 PAEs 代谢物（MCPP、MECPP、MEHHP、MEOHP、MBzP、MiBP、MBP 和 MEP）纳入分析。测定血清尿酸并确定高尿酸血症病例。利用多变量广义线性模型、暴露-反应（E-R）函数和加权量子和（WQS）回归研究 PAEs 代谢物与血清尿酸浓度和高尿酸血症风险的关系。使用 SII 指数评估系统性免疫炎症（SII），并使用因果中介效应模型探讨其中介效应：分析了2003-2018年NHANES调查中10633名美国成年人的数据。除MEP外，单个PAEs代谢物和总PAEs代谢物与血清尿酸浓度升高和高尿酸血症风险相关。PAEs代谢物与血清尿酸浓度和高尿酸血症风险的E-R函数显示出明显的正相关，大多数曲线接近线性关系。WQS回归结果表明，PAEs代谢物混合物与血清尿酸升高和高尿酸血症风险有关，MBzP被确定为对PAEs代谢物贡献最大的代谢物。因果中介效应模型发现，SII对PAEs代谢物与血清尿酸和高尿酸血症风险的关系有明显的中介作用：结论：尿中单个和混合 PAEs 代谢物与血清尿酸浓度升高和高尿酸血症风险有关。MBzP 对总体影响的贡献最大。SII改变可能是PAEs代谢物影响血清尿酸浓度和高尿酸血症风险的重要生物学机制。

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Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation

Background

Previous studies found that urinary phthalates (PAEs) metabolites may be associated with increased serum uric acid concentration and hyperuricemia risk. However, no population-based study has investigated the underlying biological mechanisms.

Methods

This nationwide cross-sectional study analyzed the data from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Urinary PAEs metabolites were measured and 8 PAEs metabolites (MCPP, MECPP, MEHHP, MEOHP, MBzP, MiBP, MBP, and MEP) were incorporated into the analysis. Serum uric acid was determined and hyperuricemia cases were identified. Multi-variable generalized linear model, exposure-response (E-R) function and weighted quantile sum (WQS) regression were utilized to investigate the relationships of PAEs metabolites with serum uric acid concentration and hyperuricemia risk. Systemic immune inflammation (SII) was assessed using the SII index and its mediation effects were explored using causal mediation effect model.

Results

Data from 10,633 US adults in the NHANES 2003–2018 was analyzed. Except for MEP, individual PAEs metabolite and total PAEs metabolites were associated with increased serum uric acid concentration and hyperuricemia risk. E-R function of PAEs metabolites with serum uric acid concentration and the risk of hyperuricemia showed significantly positive associations with most curves in a nearly linear relationship. WQS regression showed that the mixture of PAEs metabolites was related to elevated serum uric acid and hyperuricemia risk, and MBzP was identified as the most contributing PAEs metabolite. The causal mediation effect model found that SII significantly mediated the relationships of PAEs metabolites with serum uric acid and hyperuricemia risk.

Conclusion

Individual and mixture of urinary PAEs metabolites were associated with increased serum uric acid concentration and the risk of hyperuricemia. MBzP exhibited the highest contribution to the overall effects. SII alteration may be an important biological mechanism underlining the impact of PAEs metabolites on serum uric acid concentration and hyperuricemia risk.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.