重度抑郁症患者的 DTI-ALPS 指数较低：与疲劳相关

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-11-05 DOI:10.1016/j.bbr.2024.115323

Wenxin Bao , Ping Jiang , Peiwei Xu , Hai Lin , Jiaqi Xu , Mingfeng Lai , Jianmin Yuan , Jiajun Xu

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引用次数: 0

摘要

背景和目的：沿血管周围间隙的弥散张量成像（DTI-ALPS）是一种可深入了解颅内废物清除过程的指标。淋巴系统功能障碍被认为在重度抑郁症（MDD）的发病过程中起着一定的作用。此外，疲劳--MDD 的常见前兆--也与中枢神经系统（CNS）的废物清除功能密切相关，这进一步强调了有效清除废物在 MDD 中的重要性。然而，将 DTI-ALPS 指数的改变与 MDD 联系起来的证据仍然有限。本研究旨在调查 MDD 患者的 DTI-ALPS 指数变化，并探索 DTI-ALPS 指数变化、疲劳和 MDD 存在之间的潜在相互作用：研究共纳入了 46 名 MDD 患者和 55 名健康对照者（HC）。所有参与者均使用同一台 3-T MRI（3-特斯拉磁共振成像）扫描仪进行了弥散张量成像。我们评估了两组患者的 DTI-ALPS 指数，并使用查尔德疲劳量表（CFS）来评估疲劳程度，同时使用 17 项汉密尔顿抑郁评定量表（HAMD-17）来评估患者的抑郁严重程度。我们比较了MDD组和HC组的DTI-ALPS指数和临床特征，并通过中介分析探讨了DTI-ALPS指数、CFS评分和是否患有MDD之间的关系：MDD 患者右半球的 DTI-ALPS 指数（DTI-ALPS-R）明显较低（t = 2.41，P = 0.02）。MDD 患者的 CFS 量表得分明显高于 HC 患者（t = 13.12，P 结论：MDD 患者的 CFS 量表得分明显高于 HC 患者（t = 13.12，P 结论：MDD 患者的 CFS 量表得分明显高于 HC 患者）：我们的研究发现，MDD 患者的 DTI-ALPS 指数降低。这种降低似乎有助于疲劳症状的积累，从而导致 MDD 的发展。这些发现可能为 MDD 的发病机制提供了一个新的视角，提出了 MDD 潜在的新生物标志物，并为 MDD 的治疗提供了新的见解。

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Lower DTI-ALPS index in patients with major depressive disorder: Correlation with fatigue

Background and purpose

Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is an index that may provide insights into intracranial waste clearance processes. Glymphatic system dysfunction has been suggested to play a role in the development of major depressive disorder (MDD). Additionally, fatigue—a common precursor of MDD—is also closely connected to the waste clearance function of the central nervous system (CNS), further underscoring the significance of efficient waste removal in MDD. However, evidence linking altered DTI-ALPS index to MDD remains limited. This study aims to investigate the changes in the DTI-ALPS index in patients with MDD and explore the potential interplay between DTI-ALPS index alterations, fatigue, and the presence of MDD.

Material and methods

A total of 46 patients with MDD and 55 healthy controls (HC) were included in the study. All participants underwent diffusion tensor imaging using the same 3-T MRI (3-Tesla Magnetic Resonance Imaging) scanner. The DTI-ALPS index was assessed, and the Chalder Fatigue Scale (CFS) was used to evaluate fatigue levels in both groups, and the 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate the severity of depression in the patients. We compared the DTI-ALPS index and clinical characteristics between the MDD and HC group, and explored the relationship among the DTI-ALPS index, CFS scores, and the presence of MDD through mediation analysis.

Results

The DTI-ALPS index in the right hemisphere (DTI-ALPS-R) is significantly lower in patients with MDD (t = 2.41, P = 0.02). The MDD patients exhibited significantly higher scores on the CFS scales compared with HCs (t = 13.12, P <.001). Mediation analysis showed that the CFS score plays a significant mediating role between DTI-ALPS-R and the presence of MDD, acting as a full mediator (indirect effect β = −0.230, 95 % CI: [-0.388, −0.059]).

Conclusion

Our study found that patients with MDD have a reduced DTI-ALPS index. This reduction appears to contribute to the development of MDD by facilitating the accumulation of fatigue symptoms. These findings may provide a new perspective on the pathogenesis of MDD, suggest a potential new biomarker for MDD, and offer new insights for its treatment.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.