乙型肝炎病毒感染对母乳营养成分的影响：前瞻性队列研究

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2024-11-13 DOI:10.1016/j.foodchem.2024.141947

Peizhen Zhang, Huiqi Jian, Chuo Li, Lin Yao, Tiantian He, Zhangmin Tan, Jin Zhou, Yuzhu Yin

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引用次数: 0

摘要

有关乙型肝炎病毒（HBV）感染对母乳成分影响的数据很有限，国际上也没有就 HBV 阳性母亲的新生儿营养管理达成共识。我们假设 HBV 感染会改变母乳的成分，新生儿需要额外的营养补充才能健康成长。我们开展了一项前瞻性观察性队列研究，招募了 150 名 HBV 感染孕妇，并将她们与健康对照组进行配对。多变量线性回归分析显示，HBV 组的葡萄糖和白蛋白浓度增加（平均值分别为 4.65 mmol/L 和 5.66 g/L），而乳铁蛋白浓度降低（平均值为 537.7 pg/ml）。因此，感染 HBV 的妇女所生的新生儿可能需要额外补充乳铁蛋白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effect of hepatitis B virus infection on the nutrient composition of human breast milk: A prospective cohort study

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Effect of hepatitis B virus infection on the nutrient composition of human breast milk: A prospective cohort study

There are limited data regarding the impact of Hepatitis B virus (HBV) infection on the composition of human breast milk, and there is no international consensus on the nutritional management of newborns of HBV-positive mothers. We hypothesised that HBV infection can alter the composition of breast milk and that newborns require additional nutritional supplements for healthy growth. We conducted a prospective observational cohort study that recruited 150 pregnant women with HBV infection and matched them with a healthy control group. Multivariate linear regression analysis revealed that glucose and albumin concentrations were increased in the HBV group (av. 4.65 mmol/L and av. 5.66 g/L, respectively), whereas lactoferrin concentrations decreased (av. 537.7 pg/ml). Therefore, additional lactoferrin supplementation may be necessary for newborns delivered to women with HBV infection.

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture