共轭聚合物增强型有机染料近红外电化学发光法检测啶虫脒

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2024-11-13 DOI:10.1016/j.aca.2024.343417

Xin Wen, Ying He, Ruo Yuan, Shihong Chen

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引用次数: 0

摘要

背景近红外电致化学发光（NIR-ECL）具有良好的穿透性和近乎零的背景干扰，在临床医学和生物成像中显示出独特的优势。在各类近红外电致发光发射体中，近红外有机染料因其结构可调、光学性质多样而备受研究人员关注。然而，现有的近红外染料通常具有固有的自淬效应和较差的光稳定性，因此其 ECL 效率较低，如何提高其 ECL 性能是一个巨大的挑战。在聚[(9,9-dlhexyfluoren-2,7-dlyl)-co-(anthracen-9,10-dlyl)]（PFAD）存在下进行纳米沉淀，制备出红外聚合物纳米粒子（IR PNPs）。由于 PFAD 与 IR 783 之间的共振能量转移（RET）以及 PFAD 对 IR 783 的包裹，所制备的 IR PNPs 在核心反应物三丙胺（TPrA）和 H2O2 的有效淬灭下，表现出强烈而稳定的近红外-ECL 发射，最大 ECL 波长为 802 nm。红外 PNPs 与近距离连接试验（PLA）诱导的 DNA 步行器耦合，实现了啶虫脒（ACE）分析。ACE 触发 PLA 形成双足 DNA 步行器，并进一步释放富含 G 的二级靶标（ST）。随着 ST 和 hemin 被捕获到 IR PNPs 修饰的电极上，hemin/G-四联体被组装起来消耗 H2O2，从而恢复 ECL 信号用于检测 ACE，检测限为 4.74 ×10-15 M。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Conjugated Polymer-Boosted Near-infrared Electrochemiluminescence of Organic Dye for Detecting Acetamiprid

查看原文本刊更多论文

Conjugated Polymer-Boosted Near-infrared Electrochemiluminescence of Organic Dye for Detecting Acetamiprid

Background

The near-infrared electrochemiluminescence (NIR-ECL) has excellent penetration and near zero background interference, and has shown unique advantages in clinical medicine and bioimaging. Among various types of NIR-ECL emitters, NIR organic dyes have arouse the concern of researchers due to their adjustable structure and diverse optical properties. However, the currently available NIR dyes usually have inherent self-quenching effect and poor photostability, so their ECL efficiency is low, and it is a great challenge to improve their ECL performance.

Result

Conjugated polymer-boosted NIR-ECL strategy was creatively developed to overcome ECL performance limitations of NIR dyes. IR 783, as one of heptamethine cyanine dyes, was performed a nanoprecipitation in the presence of poly[(9,9-dlhexyfluoren-2,7-dlyl)-co-(anthracen-9,10-dlyl)] (PFAD) to prepare IR polymer nanoparticles (IR PNPs). Due to resonance energy transfer (RET) from PFAD to IR 783 and encapsulation of IR 783 by PFAD, the resulting IR PNPs exhibited a strong and stable NIR-ECL emission with a maximum ECL wavelength of 802 nm under coreactant tripropylamine (TPrA) and H₂O₂ can effectively quench it. IR PNPs coupled proximity ligation assay (PLA)-induced DNA walker to achieve acetamiprid (ACE) analysis. ACE triggered PLA to form bipedal DNA walker, and further release G-rich secondary target (ST). With ST and hemin being captured on IR PNPs modified electrode, hemin/G-quadruplex was assembled to consume H₂O₂, thereby restoring ECL signal for ACE detection with a limit of detection of 4.74 ×10^-15 M.

Significance

This work opens up a new and simple way to boost NIR-ECL of organic dyes, and IR PNPs create a promising NIR-ECL platform for pesticide detection.

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.