将脂肪甘油三酯脂肪酶作为治疗代谢功能障碍相关性脂肪性肝炎的靶点：肝脏和肠道 PPARα 的作用

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2024-11-13 DOI:10.1016/j.jhep.2024.10.046

Frank J. Gonzalez, Yangliu Xia

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引用次数: 0

摘要

部分片段财务支持由美国国家癌症研究所校内研究计划资助。利益冲突声明作者声明没有与本研究相关的利益冲突，详情请参见随附的 ICMJE 披露表。PNPLA2 受胰岛素调节，在胰岛素抵抗的条件下，脂肪细胞 ATGL 的增加会导致游离脂肪酸的过量产生，这些游离脂肪酸被运送到肝脏，从而导致代谢功能障碍相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Adipose triglyceride lipase as a target for treatment of metabolic dysfunction-associated steatohepatitis: the role of hepatic and intestinal PPARα

Section snippets

Financial support

Funded by the National Cancer Institute Intramural Research Program.

Declaration of Competing Interest

The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the PNPLA2 gene in humans, hydrolyzes triacylglycerols to diacylglycerols. PNPLA2 is regulated by insulin, and under conditions of insulin resistance, increased adipocyte ATGL leads to excess production of free fatty acids that are transported to the liver resulting in metabolic dysfunction-associated

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来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.