微生物炼金术士开启蜜蜂的认知能力

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-11-13 DOI:10.1016/j.chom.2024.10.013

Huihui Sun, Guan-Hong Wang

引用次数: 0

摘要

在本期《细胞宿主与微生物》（Cell Host & Microbe）杂志上，Zhong 等人1 发现了促进蜜蜂认知功能的肠道微生物群与宿主的联系。他们发现了微生物群在脂质代谢和脂质衍生神经递质合成中的作用，而脂质衍生神经递质可调节内源性大麻素系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microbial alchemists unlock honeybee cognition

In this issue of Cell Host & Microbe, Zhong et al.¹ uncover gut microbiota-host connections that promote cognitive function in honeybees. They discover the role of the microbiota in lipid metabolism and the synthesis of lipid-derived neurotransmitters, which modulate the endocannabinoid system.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.