与年龄相关的神经心血管疾病中的淀粉样蛋白-β代谢

IF 37.6 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal Pub Date : 2024-11-11 DOI:10.1093/eurheartj/ehae655

Evmorfia Aivalioti, Georgios Georgiopoulos, Simon Tual-Chalot, Dimitrios Bampatsias, Dimitrios Delialis, Kateryna Sopova, Stavros G Drakos, Konstantinos Stellos, Kimon Stamatelopoulos

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引用次数: 0

摘要

流行病学证据表明，心脑血管疾病（包括中风、阿尔茨海默病、血管性痴呆、心脏病和外周血管疾病）的发生和预后存在共同的风险因素。有害血液信号的积累可能诱发器官型内皮功能障碍，影响血脑屏障功能和老年相关疾病的血管健康。与遗传、年龄、生活方式或心血管治疗相关的大脑和外周淀粉样β（Aβ）肽代谢失衡可能是老年相关神经心血管疾病之间缺失的一环。与 Aβ 代谢相关的基因多态性、生活方式的改变、临床实践中使用的药物以及针对 Aβ 的治疗方法可能会调节 Aβ 水平，从而影响大脑、血管和心脏疾病。这篇叙述性综述阐述了干预措施对大脑、脑脊液、血液和外周心脏或血管组织中 Aβ 代谢的影响。此外，还讨论了 Aβ 作为与年龄有关的神经心血管疾病之间的联系对临床适用性的影响、知识差距以及未来展望。

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Amyloid-beta metabolism in age-related neurocardiovascular diseases

Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood–brain barrier function and vascular health in age-related diseases. Genetic-, age-, lifestyle- or cardiovascular therapy–associated imbalance of amyloid-beta (Aβ) peptide metabolism in the brain and periphery may be the missing link between age-related neurocardiovascular diseases. Genetic polymorphisms of genes related to Aβ metabolism, lifestyle modifications, drugs used in clinical practice, and Aβ-specific treatments may modulate Aβ levels, affecting brain, vascular, and cardiac diseases. This narrative review elaborates on the effects of interventions on Aβ metabolism in the brain, cerebrospinal fluid, blood, and peripheral heart or vascular tissues. Implications for clinical applicability, gaps in knowledge, and future perspectives of Aβ as the link among age-related neurocardiovascular diseases are also discussed.

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来源期刊

European Heart Journal 医学-心血管系统

CiteScore

39.30

自引率

6.90%

发文量

3942

审稿时长

1 months

期刊介绍： The European Heart Journal is a renowned international journal that focuses on cardiovascular medicine. It is published weekly and is the official journal of the European Society of Cardiology. This peer-reviewed journal is committed to publishing high-quality clinical and scientific material pertaining to all aspects of cardiovascular medicine. It covers a diverse range of topics including research findings, technical evaluations, and reviews. Moreover, the journal serves as a platform for the exchange of information and discussions on various aspects of cardiovascular medicine, including educational matters. In addition to original papers on cardiovascular medicine and surgery, the European Heart Journal also presents reviews, clinical perspectives, ESC Guidelines, and editorial articles that highlight recent advancements in cardiology. Additionally, the journal actively encourages readers to share their thoughts and opinions through correspondence.