使用功能化注射针在体内消除循环肿瘤细胞的电热疗法

IF 3.5 2区物理与天体物理 Q2 PHYSICS, APPLIED

Applied Physics Letters Pub Date : 2024-11-11 DOI:10.1063/5.0226868

Bingqi Zhang, Fengting Wang, Xiangtian Kong, Xiaoyao Zhang, Tongsheng Chen, Xinlei Li

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引用次数: 0

摘要

近年来，消除循环肿瘤细胞（CTCs）已成为抑制癌症转移的可靠途径。尽管光动力疗法和光热疗法（PTT）取得了一些进展，但由于疗效不理想或操作困难，限制了它们在临床上的应用。本文受浸入式加热器的启发，提出了一种利用功能化注射针消除外周血中四氯化碳的电热疗法（ETT）策略。CTC 可被注射针的纳米结构表面捕获，然后在通电状态下因电热转换引起的温度升高而被杀死。ETT 不仅避免了外部光源的照射，而且比 PTT 更容易、更准确地控制针头的温度。因此，本研究提出了一种更适用于消除四氯化碳的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Electrothermal therapy for the in vivo elimination of circulating tumor cells by using a functionalized injection needle

The elimination of circulating tumor cells (CTCs) has recently emerged as a reliable route to inhibit metastasis of cancer. Despite some progress of photodynamic therapy and photothermal therapy (PTT), their unsatisfying efficacy or difficult operation has limited their clinical application. Herein, inspired by an immersion heater, an electrothermal therapy (ETT) strategy for the elimination of CTCs in the peripheral blood was proposed by using a functionalized injection needle. CTCs can be captured by the nanostructured surface of the injection needle and then killed in the energized state due to the temperature increase caused by electrothermal conversion. ETT not only avoids the irradiation through an external light source but also controls the temperature of the needle more easily and accurately than PTT. Thus, this study proposes a more applicable strategy for the elimination of CTCs.

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来源期刊

Applied Physics Letters 物理-物理：应用

CiteScore

6.40

自引率

10.00%

发文量

1821

审稿时长

1.6 months

期刊介绍： Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.