钪催化费歇尔吲哚合成：复杂吲哚的高效合成

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-11-12 DOI:10.1002/ejoc.202401194

Jen-Chieh Hsieh, Vijaykumar H. Thorat, Hao-Yu Chao, Po-Han Yang

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引用次数: 0

摘要

在此，我们报告了一种经典费歇尔吲哚合成的高效钪催化反应方案，该方案可耐受多种多环底物，在大多数情况下都能轻松地以高产率构建复杂的吲哚结构。此外，为了证明反应的有效性，我们还合成了两种含有喹唑啉酮的天然生物碱、它们的类似物以及一种抗癌茚酮化合物。

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Scandium‐Catalyzed Fischer Indole Synthesis: A Highly Efficient Construction of Complicated Indoles

Herein, we report an efficient scandium‐catalytic reaction protocol for the classical Fischer indole synthesis, which can tolerate a wide variety of polycyclic substrates and allow us to easily construct complex indole structures in high yields for most cases. Moreover, in order to demonstrate the reaction efficacy, we also synthesized two quinazolinone‐containing natural alkaloids, their analog, as well as an anticancer indenoindolone compound.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.