{"title":"作为潜在子宫内膜抗癌剂的树枝状、水溶性和非聚集轴向取代硅酞菁","authors":"Turgut Keles, Gökçe Seyhan, Zekeriya Biyiklioglu, Kübra Kolci, Rengin Reis, Burak Barut","doi":"10.1002/aoc.7699","DOIUrl":null,"url":null,"abstract":"<p>In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (<b>EA-TD-Si</b> and <b>EA-TD-SiQ</b>) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of <b>EA-TD-Si</b> and <b>EA-TD-SiQ</b> were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of <b>EA-TD-Si</b> and <b>EA-TD-SiQ</b> on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that <b>EA-TD-SiQ</b> had high photodamage properties via singlet oxygen depending on the light dose, while <b>EA-TD-Si</b> did not show any DNA damage without light. In addition, <b>EA-TD-SiQ</b> had higher phototoxic effects than <b>EA-TD-Si</b> on HEC-1B cells according to the MTT assay. These results revealed the potential of <b>EA-TD-SiQ</b> to be used as a PDT agent in endometrial cancer.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"38 12","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.7699","citationCount":"0","resultStr":"{\"title\":\"Dendritic, Water-Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent\",\"authors\":\"Turgut Keles, Gökçe Seyhan, Zekeriya Biyiklioglu, Kübra Kolci, Rengin Reis, Burak Barut\",\"doi\":\"10.1002/aoc.7699\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (<b>EA-TD-Si</b> and <b>EA-TD-SiQ</b>) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of <b>EA-TD-Si</b> and <b>EA-TD-SiQ</b> were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of <b>EA-TD-Si</b> and <b>EA-TD-SiQ</b> on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that <b>EA-TD-SiQ</b> had high photodamage properties via singlet oxygen depending on the light dose, while <b>EA-TD-Si</b> did not show any DNA damage without light. In addition, <b>EA-TD-SiQ</b> had higher phototoxic effects than <b>EA-TD-Si</b> on HEC-1B cells according to the MTT assay. These results revealed the potential of <b>EA-TD-SiQ</b> to be used as a PDT agent in endometrial cancer.</p>\",\"PeriodicalId\":8344,\"journal\":{\"name\":\"Applied Organometallic Chemistry\",\"volume\":\"38 12\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.7699\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Organometallic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/aoc.7699\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.7699","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Dendritic, Water-Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent
In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (EA-TD-Si and EA-TD-SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA-TD-Si and EA-TD-SiQ on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that EA-TD-SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA-TD-Si did not show any DNA damage without light. In addition, EA-TD-SiQ had higher phototoxic effects than EA-TD-Si on HEC-1B cells according to the MTT assay. These results revealed the potential of EA-TD-SiQ to be used as a PDT agent in endometrial cancer.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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