在肌无力和疑似肌无力患者中验证德文版 SarQoL® 问卷

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Sebastian Martini, Christopher Held, Sabine Schluessel, Olivia Tausendfreund, Anna Schaupp, Michaela Rippl, Benedikt Schoser, Ralf Schmidmaier, Michael Drey
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引用次数: 0

摘要

背景德文版 SarQoL® 是一种专门针对肌肉疏松症的生活质量(QoL)问卷,但尚未经过验证,这阻碍了它的广泛使用。本研究旨在评估德文版 SarQoL® 的心理测量特性。方法通过横断面研究,在慕尼黑(德国)的两家老年病门诊机构和一家老年病急症病房招募参与者。根据欧洲老年人肌肉疏松症工作组(EWGSOP2)的算法对肌肉疏松症和可能的肌肉疏松症进行诊断。在 185 名参与者(年龄为 79.8 ± 6.1)中,77 人可能患有肌肉疏松症,51 人患有肌肉疏松症。参与者填写了 SarQoL® 和欧洲生活质量 5 维度 (EQ-5D) 问卷。结果与对照组相比,肌肉疏松症受试者(p = 0.002)和疑似肌肉疏松症受试者(p < 0.001)的 SarQoL® 分数较低,这表明其具有良好的鉴别力。研究发现,肌肉疏松受试者具有一致的构建效度:与 EQ-5D 类似构建的领域具有中度到高度的相关性:"日常生活活动"(r = -0.58,p < 0.001)、"行动能力"(r = -0.72,p < 0.001),而与不同构建相关的领域,如 "疼痛"(r = -0.32,p < 0.022),则具有较低的相关性。在可能患有肌肉疏松症的受试者中也发现了类似的相关性。Cronbach's alpha 为 0.8。测试-重测可靠性极佳(类内相关系数 = 0.96;95% CI = 0.91-0.99),没有观察到地板/天花板效应。德国 SarQoL® 是测量 65 岁肌少症和疑似肌少症患者 QoL 的有效而可靠的工具,现在可用于德语人群的流行病学研究和临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validation of the German version of the SarQoL® questionnaire in sarcopenic and probable sarcopenic patients

Background

The German version of the SarQoL®, a sarcopenia-specific quality of life (QoL) questionnaire, has not been validated hindering its widespread use. This study aimed to evaluate the psychometric properties of the German SarQoL®.

Methods

Via a cross-sectional study participants were recruited in two geriatric outpatient facilities and one acute geriatric ward in Munich (Germany). Sarcopenia and probable sarcopenia were diagnosed with the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm. From 185 participants (age 79.8 ± 6.1), 77 had probable sarcopenia, and 51 had sarcopenia. Participants completed the SarQoL® and the European Quality-of-Life 5-Dimension (EQ-5D) questionnaires. The validation included examination of the discriminative power, construct validity, internal consistency, test-retest reliability, and floor/ceiling effects.

Results

Lower SarQoL®scores for sarcopenic (p = 0.002) and probable sarcopenic subjects (p < 0.001) compared to controls indicated good discriminative power. Consistent construct validity was found for sarcopenic subjects: moderate to high correlations with domains capturing similar constructs of the EQ-5D: ‘Activities of daily living’ (r = -0.58, p < 0.001), ‘Mobility’ (r = -0.72, p < 0.001) and low correlations with domains related to different constructs like ‘Pain’ (r = -0.32, p < 0.022). Similar correlations were found for probable sarcopenic subjects. The Cronbach’s alpha was 0.8. Test-retest reliability was excellent (intraclass coefficient correlation of = 0.96; 95% CI = 0.91–0.99), and no floor/ceiling effects were observed.

Conclusion

QoL was similarly reduced in both patient cohorts compared to controls. The German SarQoL® is a valid and reliable instrument for measuring QoL in patients > 65 years of age with sarcopenia and probable sarcopenia and can now be used in epidemiological studies and clinical trials in a German-speaking population.

Trial registration

German Clinical Trials Register (DRKS)-ID: DRKS00020504 (March 12th, 2021) .

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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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