可重复使用的辅助催化剂，用于腈与醇的通用和选择性α-烷基化反应†。

IF 9.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2024-10-21 DOI:10.1039/D3GC04436J

Zhuang Ma, Zechen Wu, Carsten Kreyenschulte, Stephan Bartling, Henrik Lund, Matthias Beller and Rajenahally V. Jagadeesh

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引用次数: 0

摘要

报告了一种钴催化的腈与醇的α-烷基化反应。利用这种直接借氢的方法，一系列取代和官能化的腈类可以很容易地与苄基、杂环和脂肪醇偶联，制备出各种官能化的腈类，收率从好到优（70 个实例）。这种合成的关键是在掺杂 N 的碳上使用特定的钴纳米颗粒，这种纳米颗粒是通过热解氯化钴、氯化锌、D-氨基葡萄糖盐酸盐和胶态二氧化硅混合在一起就地生成的模板材料，然后去除二氧化硅而制备的，非常方便。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reusable Co-catalysts for general and selective α-alkylation of nitriles with alcohols†

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Reusable Co-catalysts for general and selective α-alkylation of nitriles with alcohols†

A general cobalt-catalyzed α-alkylation of nitriles with alcohols is reported. Utilizing this straightforward borrowing hydrogen methodology, a series of substituted and functionalized nitriles can be easily coupled with benzylic, heterocyclic, and aliphatic alcohols to prepare diverse functionalized nitriles in good to excellent yields (>70 examples). Key for this synthesis is the use of specific cobalt-nanoparticles supported on N-doped carbon, which were conveniently prepared by pyrolysis of a templated material generated in situ by mixing cobalt chloride, zinc chloride, D-glucosamine hydrochloride, and colloidal silica, and subsequent removal of the silica.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.