拆分链条：超基础胰岛素类似物揭示了激素清除的氧化还原机制

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2024-11-11 DOI:10.1038/s41467-024-54006-6

Michael A. Weiss

引用次数: 0

摘要

Kjeldsen 及其同事在《自然-通讯》（Nature Communications）上发表报告，描述了一种基于 A 链和 B 链分离的胰岛素氧化还原清除机制。这项研究利用了一种不受经典清除途径影响的超长效类似物，强调了药理学中的蛋白质稳定性原理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance

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Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance

Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.