Ceyda Icsel, Seyma Aydinlik, Muhittin Aygun and Veysel T. Yilmaz
{"title":"三(2-吡啶基甲基)胺阳离子第一排过渡金属糖精配合物：合成、结构和抗癌研究","authors":"Ceyda Icsel, Seyma Aydinlik, Muhittin Aygun and Veysel T. Yilmaz","doi":"10.1039/D4DT02258K","DOIUrl":null,"url":null,"abstract":"<p >A series of new cationic first-row transition metal complexes of [Mn(sac)(H<small><sub>2</sub></small>O)(tpma)](sac)·H<small><sub>2</sub></small>O (<strong>Mn</strong>), [(μ-O){FeCl(tpma)}<small><sub>2</sub></small>](sac)<small><sub>2</sub></small>·3H<small><sub>2</sub></small>O (<strong>Fe</strong>), [Co(sac)(H<small><sub>2</sub></small>O)(tpma)](sac)·H<small><sub>2</sub></small>O (<strong>Co</strong>), [Ni(H<small><sub>2</sub></small>O)<small><sub>2</sub></small>(tpma)](sac)<small><sub>2</sub></small>·2H<small><sub>2</sub></small>O (<strong>Ni</strong>), [Cu(sac)(tpma)](sac) (<strong>Cu</strong>) and [Zn(sac)(H<small><sub>2</sub></small>O)(tpma)](sac) (<strong>Zn</strong>), where sac = saccharinate and tpma = tris(2-pyridylmethyl)amine, were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS, NMR, X-ray diffraction and conductivity measurements. The cytotoxic activity of the metal complexes was evaluated <em>in vitro</em> against lung carcinoma (A549), breast adenocarcinoma (MCF7), colon (HT29), and normal BEAS-2B cell lines. <strong>Mn</strong> and <strong>Fe</strong> displayed potent cytotoxic activity in all cell lines with IC<small><sub>50</sub></small> values between 1.99 ± 0.33 and 6.65 ± 0.67 μM, while <strong>Cu</strong> moderately affected the growth of HT29 cells. However the rest of the metal complexes did not demonstrate any growth inhibitory effect. Further studies with <strong>Fe</strong> treated HT29 cells through cellular imaging analysis indicated that <strong>Fe</strong> significantly induced intracellular ROS (reactive oxygen species) accumulation, mitochondrial dysfunction and double-strand DNA breaks, and eventually caused apoptotic cell death through the intrinsic pathway.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" 1","pages":" 247-258"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cationic first-row transition metal saccharinate complexes with tris(2-pyridylmethyl)amine: synthesis, structures and anticancer studies†\",\"authors\":\"Ceyda Icsel, Seyma Aydinlik, Muhittin Aygun and Veysel T. Yilmaz\",\"doi\":\"10.1039/D4DT02258K\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A series of new cationic first-row transition metal complexes of [Mn(sac)(H<small><sub>2</sub></small>O)(tpma)](sac)·H<small><sub>2</sub></small>O (<strong>Mn</strong>), [(μ-O){FeCl(tpma)}<small><sub>2</sub></small>](sac)<small><sub>2</sub></small>·3H<small><sub>2</sub></small>O (<strong>Fe</strong>), [Co(sac)(H<small><sub>2</sub></small>O)(tpma)](sac)·H<small><sub>2</sub></small>O (<strong>Co</strong>), [Ni(H<small><sub>2</sub></small>O)<small><sub>2</sub></small>(tpma)](sac)<small><sub>2</sub></small>·2H<small><sub>2</sub></small>O (<strong>Ni</strong>), [Cu(sac)(tpma)](sac) (<strong>Cu</strong>) and [Zn(sac)(H<small><sub>2</sub></small>O)(tpma)](sac) (<strong>Zn</strong>), where sac = saccharinate and tpma = tris(2-pyridylmethyl)amine, were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS, NMR, X-ray diffraction and conductivity measurements. The cytotoxic activity of the metal complexes was evaluated <em>in vitro</em> against lung carcinoma (A549), breast adenocarcinoma (MCF7), colon (HT29), and normal BEAS-2B cell lines. <strong>Mn</strong> and <strong>Fe</strong> displayed potent cytotoxic activity in all cell lines with IC<small><sub>50</sub></small> values between 1.99 ± 0.33 and 6.65 ± 0.67 μM, while <strong>Cu</strong> moderately affected the growth of HT29 cells. However the rest of the metal complexes did not demonstrate any growth inhibitory effect. Further studies with <strong>Fe</strong> treated HT29 cells through cellular imaging analysis indicated that <strong>Fe</strong> significantly induced intracellular ROS (reactive oxygen species) accumulation, mitochondrial dysfunction and double-strand DNA breaks, and eventually caused apoptotic cell death through the intrinsic pathway.</p>\",\"PeriodicalId\":71,\"journal\":{\"name\":\"Dalton Transactions\",\"volume\":\" 1\",\"pages\":\" 247-258\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-11-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dalton Transactions\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/dt/d4dt02258k\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dalton Transactions","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/dt/d4dt02258k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Cationic first-row transition metal saccharinate complexes with tris(2-pyridylmethyl)amine: synthesis, structures and anticancer studies†
A series of new cationic first-row transition metal complexes of [Mn(sac)(H2O)(tpma)](sac)·H2O (Mn), [(μ-O){FeCl(tpma)}2](sac)2·3H2O (Fe), [Co(sac)(H2O)(tpma)](sac)·H2O (Co), [Ni(H2O)2(tpma)](sac)2·2H2O (Ni), [Cu(sac)(tpma)](sac) (Cu) and [Zn(sac)(H2O)(tpma)](sac) (Zn), where sac = saccharinate and tpma = tris(2-pyridylmethyl)amine, were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS, NMR, X-ray diffraction and conductivity measurements. The cytotoxic activity of the metal complexes was evaluated in vitro against lung carcinoma (A549), breast adenocarcinoma (MCF7), colon (HT29), and normal BEAS-2B cell lines. Mn and Fe displayed potent cytotoxic activity in all cell lines with IC50 values between 1.99 ± 0.33 and 6.65 ± 0.67 μM, while Cu moderately affected the growth of HT29 cells. However the rest of the metal complexes did not demonstrate any growth inhibitory effect. Further studies with Fe treated HT29 cells through cellular imaging analysis indicated that Fe significantly induced intracellular ROS (reactive oxygen species) accumulation, mitochondrial dysfunction and double-strand DNA breaks, and eventually caused apoptotic cell death through the intrinsic pathway.
期刊介绍：
Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.
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