金(I)催化双(吲哚-3-基)炔酰胺的区域选择性环异构化以获得五元环连接的双吲哚衍生物

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-11-10 DOI:10.1002/adsc.202401052

Zhan-Shuai Xiao, Yin Wei, Min Shi

{"title":"金(I)催化双(吲哚-3-基)炔酰胺的区域选择性环异构化以获得五元环连接的双吲哚衍生物","authors":"Zhan-Shuai Xiao, Yin Wei, Min Shi","doi":"10.1002/adsc.202401052","DOIUrl":null,"url":null,"abstract":"A gold(I)-catalyzed regioselective cycloisomerization of bis(indol-3-yl)-ynamides for the rapid construction of five-membered ring linked bisindole derivatives has been reported, affording the desired products in the range of 72% - 94% yields under mild conditions along with broad substrate scope. Moreover, DFT calculation of the NBO (natural bond orbital) charge supports the origin of its regioselectivity.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"70 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gold(I)-Catalyzed Regioselective Cycloisomerization of Bis(indol-3-yl)-ynamides to Access Five-membered Ring Linked Bisindole Derivatives\",\"authors\":\"Zhan-Shuai Xiao, Yin Wei, Min Shi\",\"doi\":\"10.1002/adsc.202401052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A gold(I)-catalyzed regioselective cycloisomerization of bis(indol-3-yl)-ynamides for the rapid construction of five-membered ring linked bisindole derivatives has been reported, affording the desired products in the range of 72% - 94% yields under mild conditions along with broad substrate scope. Moreover, DFT calculation of the NBO (natural bond orbital) charge supports the origin of its regioselectivity.\",\"PeriodicalId\":118,\"journal\":{\"name\":\"Advanced Synthesis & Catalysis\",\"volume\":\"70 1\",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-11-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Synthesis & Catalysis\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1002/adsc.202401052\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202401052","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

该研究报道了一种由金（I）催化的双(吲哚-3-基)炔酰胺的区域选择性环异构化反应，用于快速构建五元环连接的双吲哚衍生物。此外，对 NBO（天然键轨道）电荷的 DFT 计算也证明了其区域选择性的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Gold(I)-Catalyzed Regioselective Cycloisomerization of Bis(indol-3-yl)-ynamides to Access Five-membered Ring Linked Bisindole Derivatives

A gold(I)-catalyzed regioselective cycloisomerization of bis(indol-3-yl)-ynamides for the rapid construction of five-membered ring linked bisindole derivatives has been reported, affording the desired products in the range of 72% - 94% yields under mild conditions along with broad substrate scope. Moreover, DFT calculation of the NBO (natural bond orbital) charge supports the origin of its regioselectivity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.