乳酸发酵使 TIL 中毒

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-11-08 DOI:10.1038/s41590-024-02020-7

Brian G. Hunt, Emily Kessler, Nikhil S. Joshi

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引用次数: 0

摘要

众所周知，肿瘤浸润 T 细胞会遇到慢性抗原和缺氧，从而导致衰竭和功能障碍。新数据显示，乳酸发酵是实体瘤的一个特征，它通过单羧酸盐转运体MCT11促进T细胞吸收乳酸，从而降低这些细胞的代谢能力和抗肿瘤功能，免疫疗法可能会针对这一效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lactate fermentation intoxicates TILs

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Lactate fermentation intoxicates TILs

Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunction. New data show that lactate fermentation, a characteristic of solid tumors, promotes the uptake of lactate into T cells via the monocarboxylate transporter MCT11, which reduces the metabolic fitness and anti-tumor function of these cells, an effect that might be targeted by immunotherapy.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.