虚弱状态与慢性肺病风险之间的关系:基于两个国家前瞻性队列的分析

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Gui-Yu Feng, Jing-Xiao Li, Guo-Sheng Li, Jun Liu, Xiang Gao, Guan-Qiang Yan, Nuo Yang, Tao Huang, Hua-Fu Zhou
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引用次数: 0

摘要

背景虚弱指数(FI)与慢性肺部疾病(CLD)风险之间的关系仍有待进一步研究。方法与材料本研究使用中国健康与退休纵向研究(CHARLS)和英国老龄化纵向研究(ELSA)的数据调查了虚弱指数与慢性肺部疾病风险之间的关系。采用倾向得分加权法确保协变量在 FI 组间的相似分布。Wilcoxon 秩和检验用于分析有 CLD 和无 CLD 组间 FI 分数的差异。采用 Kaplan-Meier 曲线和 Cox 回归分析探讨虚弱状态与 CLD 发病率之间的关系,并进行敏感性分析进行验证。Kaplan-Meier生存率和Cox回归分析表明,与体格健壮的人相比,体弱者患CLD的风险明显升高,尤其是在CHARLS队列中的某些亚组(如女性)(p <.05)。ELSA队列也得出了类似的结果(p <.05),肯定了FI是CLD的一个强有力的预测因素。其他风险因素包括年龄、吸烟和未婚状态(p < .05)。在两个队列中,体弱者的风险始终最高(CHARLS HR = 1.54,p = .003;ELSA HR = 6.64,p < .001)。这些发现强调了体弱在CLD发展过程中的关键作用,表明有针对性的干预措施可以降低CLD风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between frailty status and risk of chronic lung disease: an analysis based on two national prospective cohorts

Background

The association between the frailty index (FI) and the risk of chronic lung diseases (CLDs) remains unexplored, warranting further research.

Methods and materials

This study investigated the relationship between FI and CLD risk using data from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA), comprising a combined sample of 9642 individuals. Propensity score weighting was used to ensure similar distribution of covariates across FI groups. The Wilcoxon rank-sum test was used to analyze differences in FI scores between groups with and without CLD. Kaplan–Meier curves and Cox regression analysis were employed to explore the association between frailty status and CLD incidence, with sensitivity analyses conducted for validation.

Results

Higher FI scores were significantly associated with increased CLD risk in both cohorts (p < .05). Kaplan–Meier survival and Cox regression analyses indicated that frail individuals have a significantly elevated risk of CLD compared to robust individuals, particularly in certain subgroups (e.g., female) within the CHARLS cohort (p < .05). The ELSA cohort yielded similar results (p < .05), affirming FI as a strong predictor of CLD. Additional risk factors identified included age, smoking, and unmarried status (p < .05). Frail individuals consistently exhibited the highest risk in both cohorts (CHARLS HR = 1.54, p = .003; ELSA HR = 6.64, p < .001). The sensitivity analysis did not substantially alter the significant associations.

Conclusion

These findings emphasize the critical role of frailty in the development of CLD, suggesting that targeted interventions could reduce CLD risk.

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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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