携带移动性可乐定抗性基因的细菌及其控制措施,最新综述

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Qi Zhang
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引用次数: 0

摘要

质粒编码的移动可乐定耐药性(MCRs)酶对可乐定的临床疗效构成了重大挑战,可乐定经常被用作治疗耐多药细菌感染的最后一种抗生素。这种转移酶催化带正电荷的磷乙醇胺添加到革兰氏阴性细菌外膜的脂质 A 上,从而促进获得可乐定耐药性。本综述旨在总结和批判性讨论 mcr 阳性细菌的分布和致病机理方面的最新进展,以及治疗这些感染的各种控制措施。此外,还分析了 mcr 基因的生态学、耐秋水仙碱机制、与其他抗生素耐药基因的共存及其对临床治疗的影响,以应对秋水仙碱耐药危机。这些见解为我们提供了一个全面认识 MCR 的视角,为未来有效对抗 mcr 阳性细菌感染的治疗方法提供了宝贵的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacteria carrying mobile colistin resistance genes and their control measures, an updated review

The plasmid encoded mobile colistin resistance (MCRs) enzyme poses a significant challenge to the clinical efficacy of colistin, which is frequently employed as a last resort antibiotic for treating infections caused by multidrug resistant bacteria. This transferase catalyzes the addition of positively charged phosphoethanolamine to lipid A of the outer membrane of gram-negative bacteria, thereby facilitating the acquired colistin resistance. This review aims to summarize and critically discuss recent advancements in the distribution and pathogenesis of mcr-positive bacteria, as well as the various control measures available for treating these infections. In addition, the ecology of mcr genes, colistin-resistance mechanism, co-existence with other antibiotic resistant genes, and their impact on clinical treatment are also analyzed to address the colistin resistance crisis. These insights provide a comprehensive perspective on MCRs and serve as a valuable reference for future therapeutic approaches to effectively combat mcr-positive bacterial infections.

Graphical Abstract

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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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