肠道微生物群与自身免疫性疾病:孟德尔随机化的启示

IF 2.5 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fangxiang Mu, Gusbakti Rusip, Florenly Florenly
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引用次数: 0

摘要

近年来,科学界开始关注肠道微生物群在自身免疫性疾病(AID)发病中的作用。尽管观察性研究显示,肠道微生物群与类风湿性关节炎、系统性红斑狼疮和多发性硬化症等自身免疫性疾病之间存在显著关联,但这些关联并不一定意味着因果关系。孟德尔随机化(MR)方法已被广泛用于研究因果关系。相关的 MR 研究结果表明,有益微生物种群的减少,尤其是双歧杆菌和乳酸杆菌的减少,以及潜在致病微生物的增加,与艾滋病风险的升高相关。鉴于 MR 在揭示艾滋病病因机制方面的创新潜力,本文概述了这一方法及其在艾滋病研究中的最新应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut microbiota and autoimmune diseases: Insights from Mendelian randomization

In recent years, the scientific community has shown interest in the role of gut microbiota in the development of autoimmune diseases (AID). Although observational studies have revealed significant associations between gut microbiota and AID like rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, these connections do not necessarily imply causality. Mendelian randomization (MR) approach has been extensively employed to investigate the causal relationship. Relevant MR study findings indicate that a reduction in beneficial microbial populations, particularly Bifidobacterium and Lactobacillus, and an increase in potential pathogenic microbes, is correlated with an elevated AID risk. Given the innovative potential of MR in unraveling the etiopathogenesis of AIDs, this article offers an overview of this methodological approach and its recent applications in AID research.

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来源期刊
FASEB bioAdvances
FASEB bioAdvances Multiple-
CiteScore
5.40
自引率
3.70%
发文量
56
审稿时长
10 weeks
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