单细胞和空间转录组学:发现人类胎盘发育和疾病

IF 2.5 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mi Tang, Liling Xiong, Jianghui Cai, Li Fan, Cheng Huang, Shimao Zhang, Ying Jin, Er-dan Luo, ShaSha Xing, Xiao Yang
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引用次数: 0

摘要

人类胎盘是一个重要的器官,包括许多不同类型的细胞,它维持着胎儿的生长和发育,对物质交换、防御、合成和免疫至关重要。胎盘细胞的异常可导致各种妊娠并发症,但其机制在很大程度上仍不清楚。近年来,单细胞和空间转录组学技术的发展证明了胎盘细胞的异质性和空间分子定位。在此,我们回顾和总结了目前的文献,展示了这些技术,并显示了正常人胎盘以及胎盘相关疾病(如子痫前期、妊娠期糖尿病、高龄产妇、复发性妊娠流产和胎盘早剥谱系障碍)中各种胎盘细胞的异质性和细胞间的交流。同时,还讨论了目前的薄弱环节和未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Single-cell and spatial transcriptomics: Discovery of human placental development and disease

Single-cell and spatial transcriptomics: Discovery of human placental development and disease

The human placenta is a vital organ, encompassing many distinct cell types, that maintains the growth and development of the fetus and is essential for substance exchange, defense, synthesis, and immunity. Abnormalities in placental cells can lead to various pregnancy complications, but the mechanisms remain largely unclear. Single-cell and spatial transcriptomics technologies have been developed in recent years to demonstrate placental cell heterogeneity and spatial molecular localization. Here, we review and summarize the current literature, demonstrating these technologies and showing the heterogeneity of various placenta cells and cell–cell communication of normal human placenta, as well as placenta-related diseases, such as preeclampsia, gestational diabetes mellitus, advanced maternal age, recurrent pregnancy loss, and placenta accreta spectrum disorders. Meanwhile, current weaknesses and future direction were discussed.

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来源期刊
FASEB bioAdvances
FASEB bioAdvances Multiple-
CiteScore
5.40
自引率
3.70%
发文量
56
审稿时长
10 weeks
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