天然产品多糖通过调节肠道微生物群缓解抗生素相关性腹泻:综述

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Yong Lai, Xin Lan, Yahui Qin, Yuankui Wei, Xi Li, Jianan Feng, Junping Jiang
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引用次数: 0

摘要

抗生素相关性腹泻(AAD)是指不适当使用抗生素后,肠道微生物群和新陈代谢紊乱而引起的腹泻。随着人们对抗生素的过度依赖,AAD 的发病率在全球范围内不断上升。最近,益生菌和益生元制剂在预防和治疗 AAD 方面的作用日益受到关注。各种益生元不仅能降低 AAD 的发病率,还能有效缩短病程和缓解症状。值得注意的是,许多从植物和真菌中提取的多糖是一类具有生物活性且含量丰富的益生元,在缓解 AAD 方面具有巨大潜力。因此,本综述旨在总结有关天然产物多糖通过调节肠道微生物群来缓解抗生素相关性腹泻的最新研究。它为探索天然产物调节肠道微生物群以缓解 AAD 的机制提供了理论依据,并为进一步开发活性益生元提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polysaccharides of natural products alleviate antibiotic-associated diarrhea by regulating gut microbiota: a review

Antibiotic-associated diarrhea (AAD) is diarrhea caused by disturbances in intestinal microbiota and metabolism following inappropriate use of antibiotics. With the over-reliance on antibiotics, the incidence of AAD is increasing worldwide. Recently, the role of probiotics and prebiotic preparations in the prevention and treatment of AAD has received increasing attention. Various prebiotics can not only reduce the incidence of AAD, but also effectively shorten the course of the disease and alleviate the symptoms. Notably, many polysaccharides derived from plants and fungi are a class of biologically active and rich prebiotics with great potential to alleviate AAD. Therefore, this review aims to summarize the latest research on natural product polysaccharides to alleviate antibiotic-associated diarrhea by modulating the gut microbiota. It provides a theoretical basis for exploring the mechanism of natural product modulation of gut microbiota to alleviate AAD, and provides a reference for further development of active prebiotics.

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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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