骨髓中训练有素的免疫力自身免疫的枢纽

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-11-07 DOI:10.1016/j.stem.2024.10.008

Mihai G. Netea, Leo A.B. Joosten

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引用次数: 0

摘要

据描述，在骨髓免疫细胞祖细胞中不适当地诱导训练有素的免疫力是慢性炎症过程的基础。米尔斯及其同事最近在《细胞干细胞》（Cell Stem Cell）杂志上发表的论文表明，适应不良的训练有素的免疫力会驱动自身免疫过程中的炎症1，从而开辟了自身免疫研究的新领域。

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Trained immunity in the bone marrow: Hub of autoimmunity

An inappropriate induction of trained immunity in the bone marrow progenitors of immune cells has been described to underlie chronic inflammatory processes. Mills and colleagues’ recently published paper in Cell Stem Cell shows that maladaptive trained immunity drives inflammation in autoimmune processes,¹ opening a new area of research in autoimmunity.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.