孕妇孕期贫血与婴儿出生结果：印度东部马哈拉施特拉邦的前瞻性队列研究

IF 3.8 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2024-11-01 DOI:10.1016/j.cdnut.2024.104476

Jacqueline M Lauer , Shilpa Bhaise , Varsha Dhurde , Abigail Gugel , Miloni Shah , Patricia L Hibberd , Archana Patel , Lindsey M Locks

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引用次数: 0

摘要

背景妊娠期贫血可能与婴儿不良预后有关，但其后果可能因病因和时间而异。方法我们对 200 名孕妇进行了一项前瞻性队列研究。我们对 200 名孕妇进行了前瞻性队列研究，在妊娠头三个月采集静脉血，通过氰红血红蛋白分析评估血红蛋白、微量营养素状况（铁蛋白、维生素 B12 和叶酸）和炎症（C 反应蛋白）。此外，还使用血红蛋白仪对母亲在妊娠头三个月和第三个月以及婴儿在妊娠 6 周时的毛细血管样本中的血红蛋白进行了评估。结果在妊娠头三个月，静脉血 Hb 偏高（与正常值相比）与较低的出生胎龄[β：-1.0 wk，95% 置信区间 (CI)：-1.9，-0.2]和较高的出生体重-胎龄百分位数（β：20.1，95% CI：9.0，31.2）显著相关。轻度贫血、中度贫血和毛细血管 Hb 偏高（与正常值相比）与出生体重偏低显著相关（β：-147.7克，95% CI：-243.4，-51.7；β：-77.7克，95% CI：-123.9，-31.4；β：-236.0克，95% CI：-478.0，-48.1）和胎龄出生体重百分位数（β：-7.3，95% CI：-13.7，-0.9；β：-8.4，95% CI：-14.1，-2.8；β：-8.9，95% CI：-15.9，-1.9）。较高的血清铁蛋白与较高的出生体重（β：2.0 克，95% CI：0.1，3.9）和出生胎龄（β：0.01 周，95% CI：0.00，0.01）显著相关。结论孕妇孕期贫血与婴儿预后之间的关系不一，需要进一步研究以更好地了解这些关系。

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Maternal Anemia during Pregnancy and Infant Birth Outcomes: A Prospective Cohort Study in Eastern Maharashtra, India

Background

Anemia during pregnancy may be associated with poor infant outcomes, although its consequences may vary based on etiology and timing.

Objectives

We examined the associations between anemia and anemia-related biomarkers during pregnancy and infant outcomes [birthweight, gestational age at birth, birthweight-for-gestational age percentile, and infant hemoglobin (Hb) at 6 wk of age] in Nagpur, Eastern Maharashtra, India.

Methods

We conducted a prospective cohort study of 200 pregnant women. In the first trimester, venous blood was collected to assess Hb via cyanmethemoglobin analysis, micronutrient status (ferritin, vitamin B12, and folate), and inflammation (C-reactive protein). Hb was also assessed in capillary samples using a hemoglobinometer in the first and third trimesters for mothers and at 6 wk for infants. Associations were assessed using generalized linear models controlling for background characteristics.

Results

In the first trimester, high (compared with normal) venous Hb was significantly associated with lower gestational age at birth [β: −1.0 wk, 95% confidence interval (CI): −1.9, −0.2] and higher birthweight-for-gestational age percentile (β: 20.1, 95% CI: 9.0, 31.2). Mild anemia, moderate anemia, and high (compared with normal) capillary Hb were significantly associated with lower birthweight (β: −147.7 g, 95% CI: −243.4, −51.7; β: −77.7 g, 95% CI: −123.9, −31.4; and β: −236.0 g, 95% CI: −478.0, −48.1) and birthweight-for-gestational age percentile (β: −7.3, 95% CI: −13.7, −0.9; β: −8.4, 95% CI: −14.1, −2.8; and β: −8.9, 95% CI: −15.9, −1.9). Higher serum ferritin was significantly associated with higher birthweight (β: 2.0 g, 95% CI: 0.1, 3.9) and gestational age at birth (β: 0.01 wk, 95% CI: 0.00, 0.01). In the third trimester, mild anemia was significantly associated with lower gestational age at birth (β: −0.5 wk, 95% CI: −0.7, −0.3).

Conclusions

Associations between maternal anemia during pregnancy and infant outcomes were mixed indicating further studies are needed to better understand these relationships.

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