皮下注射麻腮风疫苗后呼吸道中麻疹减毒活疫苗病毒的检测。

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-04-15 DOI:10.1093/infdis/jiae537

Timothy A Watkins, Jacqueline K Brockhurst, Gregory Germain, Diane E Griffin, Ellen F Foxman

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引用次数: 0

摘要

麻疹减毒活疫苗在预防麻疹和诱导呼吸道粘膜免疫方面非常有效，但其机制尚不清楚。我们的研究表明，健康儿童（5/20）和猕猴（6/8）皮下注射麻疹-腮腺炎-风疹（MMR）疫苗 7-21 天后，呼吸道中经常检测到减毒麻疹病毒（LAMV）RNA。从 2 只猕猴的肺部分离出了可复制的 LAMV，但没有证据表明它传播给了未接种疫苗的个体。这些观察结果表明，接种麻腮风疫苗后，呼吸道中的 LAMV 可能会在产生强大的粘膜免疫力方面发挥作用。

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Detection of Live Attenuated Measles Virus in the Respiratory Tract Following Subcutaneous Measles-Mumps-Rubella Vaccination.

The live attenuated measles vaccine is extremely effective in preventing measles and induces mucosal immunity in the respiratory tract; however, the mechanism is not known. We show that live attenuated measles virus (LAMV) RNA is frequently detected in the respiratory tract 7-21 days after subcutaneous measles-mumps-rubella (MMR) vaccination in healthy children (n = 5/20) and macaques (n = 6/8). Replicating LAMV was isolated from the lungs of 2 macaques, with no evidence of transmission to unvaccinated individuals. These observations suggest that LAMV in the respiratory tract may play a role in the development of robust mucosal immunity following MMR vaccination.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.