嵌合抗原受体 T 细胞疗法后，致命的播散性粘菌感染伴有血培养阳性和富贵病紫癜，并发嗜血细胞淋巴组织细胞增多症

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-10-29 eCollection Date: 2024-11-01 DOI:10.1093/ofid/ofae647

Takahiro Matsuo, Sebastian Wurster, Doina Ivan, Rachel Hicklen, Kelly McConn, Kelli A Bagwell, Fareed Khawaja, Roy F Chemaly, Dimitrios P Kontoyiannis

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引用次数: 0

摘要

我们报告了一例重度免疫抑制的癌症患者在接受CD70靶向嵌合抗原受体T细胞治疗后，因嗜血细胞性淋巴组织细胞增多症而出现的恶性真菌血症。粘孢子菌虽然罕见，但可在广泛的宿主中引起真正的真菌血症，表现范围从孤立的真菌血症到作为广泛传播、高负担感染一部分的真菌血症。

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Lethal Disseminated Mucorales Infection With Positive Blood Cultures With Purpura Fulminans Complicating Hemophagocytic Lymphohistiocytosis After Chimeric Antigen Receptor T-Cell Therapy.

We report a case of fulminant Mucorales fungemia in a heavily immunosuppressed cancer patient with hemophagocytic lymphohistiocytosis following CD70-targeted chimeric antigen receptor T-cell therapy. Although rare, Mucorales can cause true fungemia in a broad spectrum of hosts, with a range of manifestations from isolated fungemia to fungemia being part of widely disseminated, high-burden infection.

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.