纪念杰出的药物化学家莫里斯-罗宾斯教授。

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2024-11-07 DOI:10.1080/15257770.2024.2426160

Erik De Clercq

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引用次数: 0

摘要

莫里斯-J.罗宾斯在抗病毒核苷化学方面最突出的成就包括：(i) 合成了阿昔洛韦的 8-取代（甲基、氨基、溴代、碘代）衍生物；(ii) 作为单纯疱疹病毒（HSV）感染抑制剂的木豆素、(iii) 2',3'-二氨基嘌呤的 2',3'-二脱氧核苷（ddDAPR）及其 3'-叠氮和 3'-氟衍生物（分别为 AzddDAPR 和 FddDAPR）的抗艾滋病毒活性(iv)利巴韦林对 2',3'-二脱氧肌苷（ddI）和 ddDAPR 抗艾滋病毒活性的增效作用；(v)主要对疫苗病毒（VV）和水泡性口炎病毒（VSV）有活性的 S-腺苷高半胱氨酸水解酶（SAH）抑制剂；以及(vi)对水痘-带状疱疹病毒（VZV）有活性的呋喃并[2,3-d]嘧啶酮衍生物。）

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In memory of an exquisite medicinal chemist, Prof. Morris Robins.

Among the most prominent realizations of Morris J. Robins in the antiviral nucleoside chemistry are (i) the synthesis of 8-substituted (methyl-, amino-, bromo-, iodo) derivatives of acyclovir, (ii) xylotubercidin as an inhibitor of herpes simplex virus (HSV) infections, (iii) the anti-HIV activity of the 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and the 3'-azido- and 3'-fluoro derivatives thereof (AzddDAPR and FddDAPR, respectively), (iv) the potentiating effect of ribavirin on the anti-HIV activity of 2',3'-dideoxyinosine (ddI) and ddDAPR, (v) S-adenosylhomocysteine hydrolase (SAH) inhibitors principally active against vaccinia virus (VV) and vesicular stomatitis virus (VSV), and (vi) furo[2,3-d]pyrimidinone derivatives active against varicella-zoster virus (VZV).

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来源期刊

Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

6 months

期刊介绍： Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.